The purposes of acute toxicity testing are to obtain information on the biologic activity of a chemical and gain insight into its mechanism of action. The information on acute systemic toxicity generated by the test is used in hazard identification and risk management in the context of production, handling, and use of chemicals. The LD50 value, defined as the statistically derived dose that, wh...

One of the proposed mechanisms of homocysteine toxicity in human is the modification of proteins by the metabolite of Hcy, homocysteine thilolactone (HTL). Incubation of proteins with HTL has earlier been shown to form covalent adducts with ε-amino group of lysine residues of protein (called N-homocysteinylation). It has been believed that protein N-homocysteinylation is the pathological hallma...

We have successfully developed optically coded functional microbeads by co-encapsulating both bioluminescent reporter bacterial cells and fluorescent microspheres within a common alginate microbead. These microbeads harboring an individual self-identification code using fluorescent microspheres could be randomly scattered on any multi-well chip plate as long as the size of the microbeads are ma...

PURPOSE Non melanoma skin cancers (NMSC) of eyelid are uncommon. Many treatments approach are available with surgery being considered as the gold standard. Radiotherapy is an effective alternative in patients unfit for surgery. Brachytherapy (BT) might be a better therapeutic option due high radiation dose concentration to the tumor and rapid dose fall-off resulting in normal tissues sparing. T...

descriptive case report of a 42-year old woman with coetaneous vasculitis, and severe abdominal pain, which was led to diagnostic laparotomy. these presentations are probably as a side effect of methocarbamol injection. this is the first report according to our literature search (pubmed, google scholar, isi web of knowledge, proquest, md consult, science direct, scopus) about methocarbamol rela...

in recent years, biotechnology has provided the possibility of creating genetically modified (gm) organisms by transferring genes from sources such as viruses, bacteria, animals, and plants into usually unrelated species. this ability to overcome insurmountable physiological barriers by exchanging genetic materials among all living organisms is a double-edged sword. on the one hand, it allows t...

background: phenol and its derivatives like dinitrophenol and pentachlorophenol (carbolic acid) are widely used as insecticides, but they are very toxic substances. phenol is a general protoplasmic poison with corrosive local effects that denature proteins. poisoning with phenol compounds may occur by ingestion, inhalation, and absorption through skin. in this report we presented the toxicity e...

Studies of the dynamics of plant-herbivore interactions that explicitly address model robustness are important in assessing uncertainty. Hence, identifying conditions that guarantee the global stability of plant-herbivore systems can be used to assess the rationale involved in, for example, the selection of management and/or control decisions. The model used here to illustrate these issues is n...