Circumsporozoite (CS) proteins, which densely coat malaria (Plasmodia) sporozoites, contain an amino acid sequence that is homologous to segments in other proteins which bind specifically to sulfated glycoconjugates. The presence of this homology suggests that sporozoites and CS proteins may also bind sulfated glycoconjugates. To test this hypothesis, recombinant P. yoelii CS protein was examin...

Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there no cure for OA. Fucoidans, one of main therapeutic components brown algae, have emerged as promising molecules in OA treatment. However, variability between fucoidans makes difficult pursuit suitable candidate target specific pathological processes. By an vitro experimental approach chondrocytes and fib...

OBJECTIVES The goal of this study was to assess whether selectin blockade reduces myocardial platelet deposition and platelet-mediated injury after transient ischemia. BACKGROUND Selectins participate in platelet adhesion to reperfused endothelium. METHODS Thiopental-anesthetized, open-chest pigs were subjected to mechanical injury of the left anterior descending coronary artery followed by...

Circumsporozoite (CS) proteins, which densely coat malaria (Plasmodia) sporozoites, contain an amino acid sequence that is homologous to segments in other proteins which bind specifically to sulfated glycoconjugates. The presence of this homology suggests that sporozoites and CS proteins may also bind sulfated glycoconjugates. To test this hypothesis, recombinant P. yoelii CS protein was examin...

Sulphated polysaccharides from brown seaweedss comprise a complex group of macromolecules with a wide range of important biological properties such as anticoagulant, antioxidant, antiproliferative, antitumoral, anticomplementary, anti-inflammatory, antiviral, antipeptic and antiadhesive activities. Fucoidan is one of the main sulphated fucan, mostly interesting for their biological activities s...

Potensi perikanan Indonesia sangat besar namun belum berhasil seluruhnya dimanfaatkan secara optimal. Banyak faktor yang mempengaruhi tingkat keberhasilan seperti adanya hambatan penyakit dapat pertumbuhan. Pertumbuhan optimal merupakan factor utama agar mencapai produktivitas biomass ikan Penelitian ini bertujuan untuk menemumukan efektivitas herbal akuatik maupun teresterial memperoleh pertum...

The production of methane biofuel from seaweeds is limited by the hydrolysis of polysaccharides. The rumen microbiota of seaweed-eating North Ronaldsay sheep was studied for polysaccharidic bacterial isolates degrading brown-seaweed polysaccharides. Only nine isolates out of 65 utilized >90% of the polysaccharide they were isolated on. The nine isolates (eight Prevotella spp. and one Clostridiu...

Bacterial-derived lipopolysaccharides (LPS) can cause defective intestinal barrier function and play an important role in the development of inflammatory bowel disease. In this study, a nanocarrier based on chitosan and fucoidan was developed for oral delivery of berberine (Ber). A sulfonated fucoidan, fucoidan-taurine (FD-Tau) conjugate, was synthesized and characterized by Fourier transform i...