Epilepsy surgery in frontal lobe epilepsy (FLE) has less favorable seizure-free outcomes than temporal lobe epilepsies. Possible contributing factors include fast propagation patterns and large clinically silent areas which are characteristics of the frontal lobes. Bilateral frontal lobe abnormalities on MRI are another relative contraindication to epilepsy surgery. For example, bilateral encep...

The present study addresses the functional role of the temporal and frontal lobes in auditory change detection. Prior event-related potential (ERP) research suggested that the mismatch negativity (MMN) reflects the involvement of a temporofrontal network subserving auditory change detection processes and the initiation of an involuntary attention switch. In the present study participants were p...

Hemispheric shape is studied using magnetic resonance imaging and 3-D reconstructions in right-handed, male and female, European and Japanese subjects. Japanese hemispheres are relatively shorter, but wider than European hemispheres. Regions of maximal intersubject variability in hemispheric shape are present in the occipital and temporal lobes in each sample. Deviations from this general patte...

The objective was to compare brain perfusion image using 3-dimensional stereotactic surface projection analysis of N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography between Parkinson's disease patients with a high frontal assessment battery score and those with a low frontal assessment battery score. Thirty nondemented patients with Parkinson's disease were studied. ...

Visuospatial construction, traditionally viewed as a putative parietal function, also requires sustained attention, planning, organization strategies and error correction, and hence frontal lobe mediation. The relative contributions of the frontal and parietal lobes are poorly understood. To examine the contributions of parietal, frontal lobes, as well as right and left cerebral hemispheres to ...

Differences in semantic clustering and switching were examined in men with frontal lobe lesions, men with schizophrenia and healthy men. Men with frontal lobe lesions and men with schizophrenia generated fewer words than healthy men and presented intact clustering, but decreased switching during the semantic fluency task. However, after controlling for the number of words produced, between-grou...

The Wisconsin card-sorting test (WCST) is a commonly used clinical tool for the detection of frontal lobe dysfunction, specifically executive dysfunction. Patients with lesions outside the frontal lobes sometimes show deficits on the WCST, however, and some researchers have implicated hippocampal dysfunction as the cause of the deficit. But a critical role for the hippocampus seems to be untena...

OBJECTIVE The aim of this study was to use functional magnetic resonance imaging (fMRI) technique to explore the resting-state functional connectivity (rsFC) differences of the bilaterial cerebellum posterior lobe (CPL) after normal sleep (NS) and after sleep deprivation (SD). METHODS A total of 16 healthy subjects (eight males, eight females) underwent an fMRI scan twice at random: once foll...