The validity of the comparison principle in variable coefficient fully nonlinear gradient free potential theory is examined and then used to prove for partial differential equations which determine a suitable theory. approach combines notions proper elliptic branches inspired by Krylov [18] with monotonicity-duality meth...

Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesisled to the development of four cholinesterase inhibitors. These compounds can bring prolongationof the symptom-free period in some patients. This is the frst report directly comparing donepeziland rivastigmine plasma and brain levels in <span class="font...

Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesisled to the development of four cholinesterase inhibitors. These compounds can bring prolongationof the symptom-free period in some patients. This is the frst report directly comparing donepeziland rivastigmine plasma and brain levels in <span class="font...

Weinert, Brian T. and Paola S. Timiras. Physiology of Aging. Invited Review: Theories of aging. J Appl Physiol 95: 1706–1716, 2003; 10.1152/japplphysiol.00288.2003.—Several factors (the lengthening of the average and, to a lesser extent, of the maximum human life span; the increase in percentage of elderly in the population and in the proportion of the national expenditure utilized by the elder...

Hypothesizing that members of families enriched for longevity delay morbidity compared to population controls and approximate the health-span of centenarians, we compared the health-spans of older generation subjects of the Long Life Family Study (LLFS) to controls without family history of longevity and to centenarians of the New England Centenarian Study (NECS) using Bayesian parametric survi...

A new model for homogeneous nucleation of structural phase transformations, which can span the range of nucleation from classical to nonclassical, is presented. This model is extended from the classical nucleation theory by introducing driving-force dependencies into the interfacial free energy, themisfit strain energy, and the nucleus chemical free-energy change in order to capture the nonclas...

14 Allosteric regulation is found across all domains of life, yet we still lack simple, predictive theories that 15 directly link the experimentally tunable parameters of a system to its input-output response. To that end, 16 we present a general theory of allosteric transcriptional regulation using the Monod-Wyman-Changeux 17 model. We rigorously test this model using the ubiquitous simple rep...

To effectively control the stress state and spatial alignment of arch ribs in cable hoisting construction a long-span, concrete-filled, steel tube bridge ensure safety structure, it is necessary to calculate determine appropriate force. Based on actual project double-span, tubular bridge, stage left span from beginning closure taken as an example. The linear method “quiet do not move” adopted. ...