Kaposi's sarcoma-associated herpesvirus (KSHV) establishes a latent infection in the host following an acute infection. Reactivation from latency contributes to the development of KSHV-induced malignancies, which include Kaposi's sarcoma (KS), the most common cancer in untreated AIDS patients, primary effusion lymphoma and multicentric Castleman's disease. However, the physiological cues that t...

BACKGROUND Patients receiving cancer treatment are at risk for hepatitis B virus (HBV) reactivation. Ifosfamide is an alkylating agent and is considered to be one of the important drugs for the treatment of metastatic sarcoma. No association of ifosfamide and HBV reactivation has been reported so far. CASE REPORT We report a case of a 61-year-old Asian man with metastatic retroperitoneal lipo...

Repair of UV-irradiated bacteriophage in Escherichia coli by Weigle reactivation requires functional recA+ and umuD+C+ genes. When the cells were UV irradiated, the groE heat shock gene products, GroES and GroEL, were needed for at least 50% of the Weigle reactivation of the single-stranded DNA phage S13. Because of repression of the umuDC and recA genes, Weigle reactivation is normally blocked...

We examined the relationship between maternal depressive symptoms in late pregnancy and Epstein-Barr virus reactivation before delivery. In this prospective observational study, prevalence of Epstein-Barr virus reactivation within one week before delivery was compared between 163 pregnant women with depressive symptoms at 33 to 34 weeks of gestation and a computer-generated control group of 163...

Discussions:Costs for HBV reactivation management were estimated 688 yen per person in selective vaccination strategy compared with 350 yen per person in universal vaccination strategy, with annual discount rate of 3%. On‐one way sensitivity analysis, estimated costs were sensitive to annual discount rates and risks of HBV infections. Absolute difference in the HBV management costs was relative...

In the absence of sensory input, neuronal networks are far from being silent. Whether spontaneous changes in ongoing activity reflect previous sensory experience or stochastic fluctuations in brain activity is not well understood. Here we describe reactivation of stimulus-evoked activity in awake visual cortical networks. We found that continuous exposure to randomly flashed image sequences ind...

Objective: To establish cell model of herpes simplex virus type 2 latent infection and reactivation in SHSY5Y cells. Methods: Effects of ACV on SH-SY5Y cells were observed after cells were treated with ACV concentrations of 20, 40, 60, 80, 100, 120, or 140 μmol/L, and also cells morphology was observed under phase contrast microscope after HSV-2 was inoculated into SH-SY5Y cells using MOI of 0....

conclusions the causes leading to fracture of the humerus during the act of a throw are discussed and the management strategies utilized. introduction five patients presented to the emergency department of a tertiary referral teaching hospital with atraumatic fractures of their humerus sustained during a recreational dodgeball tournament. case presentation the patients were young healthy indivi...

background: floating knee, referred to as ipsilateral fractures of the femur and tibia, is usually associated with several complications and mortality. this study was designed to present our experience with treatment of this injury throughout; age, sex, mechanism of injury, associated injuries, method and results of treatment, and complications of floating knee are discussed. materials and meth...

introduction: fractures of the orbital floor, which are caused by various mechanisms, result in the herniation of periorbital tissue into the paranasal sinuses and its subsequent complications. early diagnosis using various techniques and reduction of fractures are necessary to preserve ocular function and esthetic. use of an endoscope has been associated with some advantages, including a decre...