نتایج جستجو برای: fractionated radiation
تعداد نتایج: 245907 فیلتر نتایج به سال:
BACKGROUND Following the demonstration that histone deacetylase inhibitors enhanced experimental radiation-induced clonogenic suppression, the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study, combining fractionated radiotherapy with daily vorinostat for pelvic carcinoma, was designed to evaluate both clinical and novel biomarker endpoints, the latter relating to pharmacodynamic indicators...
The new bioreductive drug 3-amino-1,2,4-benzotriazine 1,4-dioxide (SR 4233) shows a high selective cytotoxicity for hypoxic cells, both in vitro and in tumors in vivo. In the present experiments, we have tested the hypothesis that this selective killing of hypoxic cells might be exploited by taking advantage of the fluctuating hypoxia in tumors by use of a multidose regimen of SR 4233 with mult...
Investigation of mutational specificity at low doses has generally not been possible since the number of induced mutants may be similar or significantly lower than the spontaneous background. The use of a low-dose fractionated exposure protocol in TK6 human lymphoblasts results in an incremental accumulation of mutants induced by individual 20 cGy gamma-ray exposures. Therefore, the frequency o...
Whether fractionation decreases the risk of breast cancer induced by low-LET radiation is a question of some importance. Analyses of the data for TB cohorts who were exposed to multiple fluoroscopies show an apparently similar breast cancer risk compared with those for the acutely exposed A-bomb survivors. However, the fluoroscopy cohorts were subjected to very much lower-energy photons (60-80 ...
A section of this issue of TCRT focuses on four articles dealing with technological advances in brain and spine radiosurgery. With the evolution of radiation technology to allow for high precision image-guided radiotherapy as an integrated part of mainstream linear accelerators, the practice of stereotactic radiosurgery (SRS) is commonly applied to the brain and is rapidly developing as an attr...
A retrospective study of 16 dogs with macroscopic soft tissue sarcomas was performed to evaluate response to a four-fraction radiotherapy protocol (prescribed dose of 32 Gy). Radiation was well tolerated with minimal side effects. The overall response rate was 50%, with seven partial responses and one complete response. The median time to progression was 155 days, and the median survival time w...
Patients with early stage high-risk prostate cancer (prostate specific antigen > 20, Gleason score > 7) are at high risk of recurrence following prostate cancer irradiation. Radiation dose escalation to the prostate may improve biochemical-free survival for these patients. However, high rectal and bladder dose with conventional three-dimensional conformal radiotherapy may lead to excessive gast...
A genetically engineered, nonneurotropic herpes simplex virus (R7020) with a proven safety profile in both animals and humans was found effective in the treatment of large xenotransplanted tumors arising from a radiation- and chemotherapy-resistant human epidermoid carcinoma and a hormone-refractory prostate adenocarcinoma. R7020 replicated to high titer and caused rapid regression of the human...
Breast-conserving surgery followed by radiotherapy is the standard of care for most women with early-stage breast cancer, resulting in excellent long-term survival. Post-treatment, however, the rate of second breast cancers is significant; for example, the average ipsilateral second-cancer rate from four long-term studies is 13% after 15 years, and increases with still longer follow-up times. R...
Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT...
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