Lung disease caused by Mycobacterium abscessus is increasing, and current clarithromycin-based treatment regimens are only moderately effective. Here, we determined the effect of clarithromycin-vancomycin combination against M. abscessus complex isolates in vitro Synergy was found with a fractional inhibitory concentration index (FICI) score of ≤0.5 and a 4- to 10-fold decrease in MIC.

MICs of six broad-spectrum biocides and two specific metabolic inhibitors and fractional inhibitory concentration indexes (FICIs) for controlling a sulfide-producing consortium were determined. Nitrite was synergistic (FICI<1) with all but one biocide due to its specific inhibition of dissimilatory sulfite reductase. Hence, combining nitrite with biocides allows more efficient and cost-effectiv...

A broth dilution assay was used to determine the in vitro susceptibilities of 10 ocular isolates of Bacillus cereus to clindamycin, gentamicin, and vancomycin both alone and in combination. The checkerboard technique was used to determine fractional inhibitory and bactericidal concentration indices for combinations of clindamycin-gentamicin and vancomycin-gentamicin.

dermatophyte fungi are the etiologic agents of skin infections commonly referred to as ringworm. these infections are not dangerous but as a chronic cutaneous infections they may be difficult to treat and can also cause physical discomfort for patients. they are considered important as a public health problem as well. no information is available regarding the efficacy of antifungal agents again...

this study was carried out to evaluate the antimicrobial and antioxidant effectiveness of methanolic extract and different fractions (n-butanol, ethyl acetate, chloroform and n-hexane) of c.intybus seeds. the antimicrobial activity was determined by the disc diffusion method and minimum inhibitory concentration (mic) against a panel of microorganisms (four bacterial strains, i.e. p. multocida, ...

objective: teucrium polium l. (family lamiaceae) is a wild-growing flowering plant, found abundantly in south-western asia, europe and north africa. traditionally, t. polium has been used for different pathological conditions such as gastrointestinal disorders, inflammations, diabetes and rheumatism. the purpose of this study was to evaluate the antimicrobial effect of ethanol extract of teucri...

background and objectives: presence of methicillin and multidrug resistance has associated coagulase negative staphylococci (cns) with high morbidity and mortality worldwide. the present study was carried out to study the susceptibility pattern of cns to various antimicrobial agents and to determine the prevalence of cns methicillin resistance in our hospital setting. materials and methods: a t...

toxicity of which on biological wastewater processes, humans, and the environment has been proven in various studies. in this study, the half maximal effective concentration (ec 50 ) of growth inhibition of cadmium, lead, and mercury was assessed on dominant bacterial species present in sequencing batch reactors (sbr). methods: biomass sample was obtained from the biological unit of the sbr est...

conclusions regarding clinical and laboratory standards institute (clsi) definition for vancomycin susceptibility (mic < 2 μg/ml), it seems that vancomycin may not be considered as the best antibiotic in order to treat heteroresistant vancomycin intermediate s. aureus (hvisa) and vancomycin sensitive s. aureus (vssa) infections, and a new breakpoint for vancomycin and alternative antibiotics sh...