t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...

ankylosing spondylitis (as) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. according to recent studies, erap1 is the second most common candidate gene for  as susceptibility after hla-b27. the  aim of this study was to  determine the association of erap1 gene polymorphisms with as in iranian population. the study group comprised 387 iranian as patients and 316 h...

in an earlier work we showed that for ordered fields f not isomorphic to the reals r, there are continuous 1-1 unctions on [0, 1]f which map some interior point to a boundary point of the image (and so are not open). here we show that over closed bounded intervals in the rationals q as well as in all non-archimedean ordered fields of countable cofinality, there are uniformly continuous 1-1 func...

the apoptotic protease-activating factor 1 (apaf-1) receives the death signal in the intrinsic ormitochondrial pathway of apoptosis. upon the releasing of cytochrome c from theintermembrane space of mitochondria and binding to apaf-1 molecules, a heptamericapoptosome complex is formed and triggers the downstream cascade of caspases. here, for thefirst time we present spontaneous mutations and r...

energy-based optimized design of polymer fiber-reinforced tunnel lining mohammad safi                   analysis of underwater tunnels considering strain-softening behavior in plastic zone ahmad fahimifar; hamed ghadami; masoud ahmadvand; arvin abdolmaleki                                 the effect of operational parameters on penetration rate of a tbm using artificial neural networks- a case s...

background: human t-lymphotropic virus type i is the etiologic agent of two distinct human diseases, adult t-cell leukemia or lymphoma and a chronic, progressive demyelinating disorder. the aim of this work was to investigate the seroprevalence of htlv-1/2 among high risk patients (thalassemic and hemodialysis) in charmahal-va-baktiari province, center of iran. methods: using elisa, a total of ...

characterization of isolated pigeon paramyxovirus-1 (pmv-1) and its pathogenicity in broiler chickens were studied. two hundred and thirty-two samples collected from 50 unvaccinated pigeons lofts suspected to newcastle disease from private houses and bird markets from ahvaz , iran. swab samples from cloaca and oropharynx of live pigeons and from trachea, lung, liver, spleen, kidney, brain, prov...

intercellular adhesion molecule-1 (icam-1) lys469glu (k469e) polymorphism and gly 241arg (g241r) polymorphism might play important roles in cancer development and progression. however, the results of previous studies are inconsistent. the aim of this study was to evaluate the association between icam-1 k469e and g241r polymorphisms and the risk of cancer by meta-analysis.a comprehensive literat...