Antimycotic bifonazole (BIF) is a very hydrophobic compound, which is a major drawback for obtaining topical pharmaceutical formulations with optimal bioavailabiliy and for the penetration into hydrophilic human nail matrices. Cyclodextrins may increase local drug delivery by enhancing the drug release and/or permeation. The binary systems between bifonazole and β-cyclodextrin were prepared in ...

Advantages of the supercritical fluid (SCF) process compared to the conventional solution stirring method (CSSM) in the preparation of daidzein-hydroxypropyl-β-cyclodextrin (HPβCD) complexes were investigated. Formation of daidzein/ HPβCD inclusion complexes was confirmed by Fourier transformed-infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and sc...

Scaffold provides a suitable medium for cell growing and drug delivery while enhancing the cell transplantation efficiency. In this project, nanofibrous scaffolds were fabricated through electrospinning of Polycaprolactone (PCL) and Gelatin (GE). Processing parameters and solution parameters were optimized to achieve the desired properties of PCL/GE nanofibers. Scanning Electron Microscopy (SEM...

A method to measure the deuterium concentration in basic solutions, using Attenuated Total Reflection Fourier Transformed Infrared Spectroscopy (ATR-FTIR) is described. Deuterium quantification is based on the O-D bond stretching peak. A calibration curve is drawn, representing the peak intensity versus the deuterium percentage in a neutral solution. No calibration curve can be obtained with ba...

In this study, the potential of attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectral imaging as a technique to determine the sequence of line crossings was examined. The technique was successful in determining the sequence of heterogeneous line intersections produced using ballpoint pens and laser printers. By imaging at characteristic frequencies, it was possible to form...

The Environmental Protection Agency’s open-path Fourier transform infrared (OP-FTIR) activities include passive and active measurements in several stack and fugitive emission monitoring applications. Extensive research has been devoted during the past two years to evaluate and validate various OP-FTIR technologies for the identification and detection of toxic industrial compounds and chemical w...

Vibrational spectroscopy (VS) is the analysis of molecular properties based on vibrations at the molecular level and it is highly selective1. VS produces a spectral fingerprint of a material, such as an active pharmaceutical ingredient (API), so is well-suited to both identify and verify the API raw material and its presence in a final product. There are three related analytical techniques that...

the present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (pvp) and ethyl cellulose (ec) using a d-optimal mixture design. the prepared transdermal patches were subjected to different physicochemical evaluation. the surface topography of the patches was examined by scanning electron microscopy (s...

researchers have found a big interest in biological application of fourier transform infrared (ftir) spectroscopy. evaluating many diseases, staging them and studying the chemical structures of different formed compounds in diseases are some of the research applications of ftir. cancer is also one of these diseases. researchers are trying to set up ftir methods to detect and diagnose cancer cel...

The attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) was employed to acquire the infrared spectra of Radix Bupleuri and its unofficial varieties: the root of Bupleurum smithii Wolff and the root of Bupleurum bicaule Helm. The infrared spectra and spectra of Fourier self-deconvolution (FSD), discrete wavelet transform (DWT), and probability neural network (PNN) of t...