BACKGROUND Effective treatments to alleviate depression in Alzheimer's disease (AD) have been scarce. OBJECTIVE To investigate the efficacy and tolerability of escitalopram in the treatment of depression in AD. METHODS In this 12-week randomized, double-blind, placebo-controlled trial with open-label, 12-week extension, AD subjects over 50 years of age, with depression defined by Olin's pro...

As measured by the number of tapeworm eggs per gram of feces, pyrantel tartrate, fed on a daily basis (Strongid C), was more effective in eliminating tapeworms than was 33 pyrantel pamoate (Strongid) administered at 8-week intervals.a Horses treated with pyrantel tartrate had an egg count of zero tapeworms by 4 weeks following the initiation of treatment. Horses treated with 33 pyrantel pamoate...

yV-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide was fed to 50 female 5-week-old Swiss mice at a dose of 0.094% by weight of diet for 46 weeks, followed by 7 weeks of the control diet. Fifty-six mice received only the control diet. Thirty-three test mice survived 40 weeks or longer and had the following tumor incidences: urinary bladder, 31/33; generalized leukemia, 23/33; lung, 6/33; and 1 uterin...

background: this study evaluated the efficacy of focal intramuscular injection of botulinum (bont) toxin type a in comparison with oral tizanidine (tzd) in treatment of post-stroke upper limb spasticity. methods: this was a double-blinded randomized clinical trial that recruited 68 patients with post-stroke upper limb spasticity. thirty-four patients received bont (dysport(®)) injections in aff...

Four new chromone derivatives, phomopsichins A-D (1-4), along with a known compound, phomoxanthone A (5), were isolated from the fermentation products of mangrove endophytic fungus Phomopsis sp. 33#. Their structures were elucidated based on comprehensive spectroscopic analysis coupled with single-crystal X-ray diffraction or theoretical calculations of electronic circular dichroism (ECD). They...

Student-athletes are susceptible to mental health problems that disrupt optimal functioning and well-being. Despite having many protective factors, student-athletes represent an at-risk subgroup of college students who experience concerns due the distress balancing multiple obligations. However, underutilize psychological services. Stigma is main barrier preventing from seeking help, literacy (...

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BACKGROUND Unilateral adult thalamic gliomas are rarely reported. In this study, the authors aimed to analyze the clinical, radiological, and pathological features of adult primary unilateral thalamus gliomas (UTGs). METHODS Clinical data of 33 UTGs in adults who underwent surgical treatment between 2005 and 2014 at the Beijing Tiantan Hospital were collected and retrospectively studied. Foll...