OBJECTIVES To determine the in vitro activity of antibiotics, including arbekacin, cefminox, fosfomycin and biapenem which are all still unavailable in India, against Gram-negative clinical isolates. METHODS We prospectively collected and tested all consecutive isolates of Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa and Acinetobacter spp. from blood, urine and sputum samples bet...

BACKGROUND Patients with community-acquired urinary tract infections (UTIs) frequently present to healthcare facilities in South Africa (SA). AIM To provide information on UTI aetiology and antimicrobial susceptibility of pathogens. METHODS We recruited women with UTI-related symptoms, who tested positive for ≥2 urine dipstick criteria (proteinuria, blood, leucocytes or nitrites) at 1 publi...

Introduction. Asymptomatic bacteriuria (ASB), occurring in 2-11% of pregnancies, is a major predisposition to the development of pyelonephritis, which is associated with obstetrical complications, such as preterm labor and low birth weight infants. The aim of this study was to determine the prevalence of ASB, the antibacterial susceptibilities of the isolated microorganisms and the associated r...

BACKGROUND Antimicrobial-resistant Neisseria gonorrhoeae is a major public health threat. Current CDC treatment guidelines for uncomplicated gonorrhoea recommend only ceftriaxone plus either azithromycin or doxycycline. Additional treatment options are needed. METHODS We used antibiotic gradient synergy testing (the Etest) to evaluate antimicrobial combinations that included a third-generatio...

The efficacy of fosfomycin in combination with vancomycin or gentamicin was evaluated in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus. After 5 days of therapy, both combinations proved to be highly effective since all rabbits had sterile vegetations.

Fig. 1. Structures of FMand FMderivatives inactivated by gene products offomA andfomB. analysis revealed the presence of six open reading frames with unknownfunctions in the sequenced fragment, in addition to the four genes necessary to FMbiosynthesis. So far studied, most antibiotic-producing Streptomyces possessed resistance genes and regulatory genes in their antibiotic production gene clust...