Fork-join and split-merge queueing systems are well-known abstractions of parallel systems in which each incoming task splits into subtasks that are processed by a set of parallel servers. A task exits the system when all of its subtasks have completed service. Two key metrics of interest in such systems are task response time and subtask dispersion. This paper presents a technique applicable t...

The replisome catalyses DNA synthesis at a DNA replication fork. The molecular behaviour of the individual replisomes, and therefore the dynamics of replication fork movements, in growing Escherichia coli cells remains unknown. DNA combing enables a single-molecule approach to measuring the speed of replication fork progression in cells pulse-labelled with thymidine analogues. We constructed a ...

In response to DNA damage during S phase, cells slow DNA replication. This slowing is orchestrated by the intra-S checkpoint and involves inhibition of origin firing and reduction of replication fork speed. Slowing of replication allows for tolerance of DNA damage and suppresses genomic instability. Although the mechanisms of origin inhibition by the intra-S checkpoint are understood, major que...

We estimated bias-corrected mean fork lengths of gillnet-caught chum salmon using a size selectivity estimate of the gillnet to test how the bias correction affects the estimated temporal pattern of chum salmon body size, during 1971–1994 and 1994–2007. Results showed bias-corrected mean fork lengths were smaller than uncorrected means. Therefore, when examining ontogenetic changes in fish size...

DNA replication requires overcoming the energetic barrier associated with the base pair melting of its double helix and a finetuned coordination between the processes of DNA unwinding and DNA replication. One intriguing question that remains poorly understood is the exact mechanism of the coupling of these two reactions. In some organisms, these activities are coupled within the same protein, l...

DNA lesions cause stalling of DNA replication forks, which can be lethal for the cell. Homologous recombination (HR) plays an important role in DNA lesion bypass. It is thought that Rad51, a key protein of HR, contributes to the DNA lesion bypass through its DNA strand invasion activity. Here, using model stalled replication forks we found that RAD51 and RAD54 by acting together can promote DNA...

A model of computer system security operation is developed based on the fork-join queueing network formalism. We introduce a security operation performance measure, and show how it may be used to performance evaluation of actual systems. Key-Words: computer system security, security attack, security vulnerability, performance evaluation, fork-join queueing networks.

In this paper we prove theorems on the interpretability of the first-order temporal logics LTL and TL into Fork Algebras. This result is part of a research project on the interpretability of logics in Fork Algebras, and has important applications towards the relational specification of properties of systems within the Argentum tool.

Structural alterations in DNA can serve as natural impediments to replication fork stability and progression, resulting in DNA damage and genomic instability. Naturally occurring polypurine mirror repeat sequences in the human genome can create endogenous triplex structures evoking a robust DNA damage response. Failures to recognize or adequately process these genomic lesions can result in loss...

BACKGROUND Stress fractures are quite common both in athletes and military recruits. The purpose of the study was to evaluate the efficacy of tuning fork in stress fractures by comparing it with three phase bone scan. METHODS The current study examined 55 subjects whose age ranged 18-28 years. X-rays of all the subjects were unremarkable. After history and clinical examination tuning fork tes...