HISTORICAL TIPS The science of “Immunology” originated in the 19th century and grass pollens were identified for the first time as the likely trigger of seasonal hay fever in the 1870s. Skin allergy testing became an accepted assessment technique around 1910. Immunoglobulin E (IgE) was identified in the 1960s. The first scholarly report of immunotherapy for allergy appeared by Noon and Freeman ...

In the United States, prostate cancer is the most frequent malignancy in men and ranks second in terms of mortality. Although recurrent or metastatic disease can be managed initially with androgen ablation, most patients eventually develop castration-resistant disease within a number of years, for which conventional treatments (eg, chemotherapy) provide only modest benefits. In the last few yea...

Breast cancer, as a heterogeneous disease, includes a wide range of pathological and clinical behaviors. Current treatment protocols, including radiotherapy, chemotherapy, and hormone replacement therapy, are mainly associated with poor response and high rate of recurrence. Therefore, more efforts are needed to develop alternative therapies for this type of cancer. Immunotherapy, as a novel str...

allergen immunotherapy involves the administration of gradually increasing quantities of specific allergens to patients with ige-mediated conditions until a dose is reached that is effective in reducing disease severity from natural exposure. in the present study we evaluated a period of six years immunotherapy allergic rhinitis and allergic asthma patients with positive skin prick test of comm...

brucellosis is an infectious disease and it seems that it affects human immune system and can cause acute, subacute and chronic clinical features. forty patients suffering from chronic brucellosis were studied for cd3+, cd4+,cd8+, cd19+, cells and cd4+/cd8+ ratio by flow cytometry before and after treatment with antibiotics and immunopotentiators. the results were compared with 15 healthy contr...

BACKGROUND Food allergy (FA) can have serious psychosocial and economic repercussions on food-allergic children and their caregivers and be associated with negative effects on their quality of life. Food allergen immunotherapy (IT) is a promising experimental therapy but can be linked to anxiety. This study investigated the effects of IT on FA-specific health-related quality of life (HRQL) over...

INTRODUCTION Treatment of food allergy essentially consists of food avoidance, but immunotherapy with food is emerging as a new therapeutic option. OBJECTIVE To evaluate clinical improvement and immunological changes in patients with peach allergy following sublingual immunotherapy (SLIT) with a Prup3 quantified peach extract. METHODS A randomized, double-blind, placebo-controlled clinical ...

specific local immunotherapy has been recently introduced as an alternative to classic subcutaneous immunotherapy in treatment of allergic rhinitis. in this study, the effects of sublingual immunotherapy (slit) on symptoms and medication score and skin prick test evaluation of patients with allergic rhinitis were investigated. in this placebo controlled trial, twenty four patients aged 5-18 yea...