and the total hepatic DNA were determined. In Experiment 3, the incidence of hepatic carcinoma was determined for various exposure durations to 0.03, 0.01, 0.003, and 0.001% 2-FAA. At 42 days after the start of administration of 0.03% 2-FAA, the uptake of TdR-3H in the hepatic DNA increased markedly. With 0.03% 2-FAA, the pulse labeling index increased progressively between 42 and 120 days, whi...

BACKGROUND Previously, the antitumour activity of some flavone-8-acetic acid (FAA) derivatives substituted with an acid function in position 2 of the benzene ring was evaluated. The most active compound resulted the one bearing a fluorine atom in position 7 of the flavone nucleus. In this paper, we evaluated new mono- or di-fluorinated FAA derivatives. MATERIALS AND METHODS The cytotoxicity t...

In the solvent system used in this laboratory (1) for the resolution of the urinary metabolites of the carcinogen N-2-fluorenylacetamide,’ the mobility of synthetic N-(6-hydroxy-2-fluorenyl)acetamide (2) on paper chromatograms was similar (RF 3.4 to 14.5)2 to that of N-(7-hydroxy-2-fluorenyl)acetamide (RF 3.4 to 15.4), a known and quantitatively important metabolite of 2FAA (cf. (3)). Prelimina...

and the total hepatic DNA were determined. In Experiment 3, the incidence of hepatic carcinoma was determined for various exposure durations to 0.03, 0.01, 0.003, and 0.001% 2-FAA. At 42 days after the start of administration of 0.03% 2-FAA, the uptake of TdR-3H in the hepatic DNA increased markedly. With 0.03% 2-FAA, the pulse labeling index increased progressively between 42 and 120 days, whi...

In the solvent system used in this laboratory (1) for the resolution of the urinary metabolites of the carcinogen N-2-fluorenylacetamide,’ the mobility of synthetic N-(6-hydroxy-2-fluorenyl)acetamide (2) on paper chromatograms was similar (RF 3.4 to 14.5)2 to that of N-(7-hydroxy-2-fluorenyl)acetamide (RF 3.4 to 15.4), a known and quantitatively important metabolite of 2FAA (cf. (3)). Prelimina...

Evidence that circadian food-anticipatory activity and temperature rhythms are absent in Bmal1 knockout mice and rescued by restoration of Bmal1 expression selectively in the dorsomedial hypothalamus was published in 2008 by Fuller et al and critiqued in 2009 by Mistlberger et al. Fuller et al have responded to the critique with new information. Here we update our critique in the light of this ...

Purpose – Infant formula is the sole nutrition and food source for many infants. Information on the free amino acid (FAA) content of formulas, particularly those that are protein hydrolysate based, is limited, despite emerging evidence for the role of FAAs in regulating eating behaviour. The purpose of this paper is to measure levels of essential, semi-essential, and nonessential FAAs in commer...

Rabbit pups ingest food, in this case milk, once a day with circadian periodicity and are a natural model of food anticipatory activity. During nursing, several sensory systems receive information about properties of the food, one of them being the olfactory system, which has received little attention in relation to synchronization by food. In addition, the olfactory bulb has a circadian pacema...

CONTEXT Iatrogenic obesity caused by atypical antipsychotics increases the rate of death from all causes. Olanzapine is a commonly prescribed atypical antipsychotic medication that frequently causes weight gain. To our knowledge, the neural correlates of this weight gain have not been adequately studied in humans. OBJECTIVE To test the hypothesis that olanzapine treatment disrupts the neural ac...

OBJECTIVE To determine whether EEG occipital alpha and frontal alpha asymmetry (FAA) distinguishes outpatients with major depression (MDD) from controls, predicts antidepressant treatment outcome, and to explore the role of gender. METHODS In the international Study to Predict Optimized Treatment in Depression (iSPOT-D), a multi-center, randomized, prospective open-label trial, 1008 MDD parti...