Cytochromes P450 (CYP) are monoxygenase enzymes involved in biotransformations of exogenous compounds in detoxification processes, but also in intoxication by generation of reactive species. CYP3A4, the most abundant isoform present in human liver, is responsible for the metabolisation of more than 60% of drugs used in therapy, leading to unwanted drug-drug interactions. The knowledge and under...