BACKGROUND Fibrous hamartoma is the key pathology of congenital pseudarthrosis of the tibia (CPT), which was shown to have low osteogenicity and high osteoclastogenicity. This study further investigated the mechanism of impaired osteoblastic differentiation of fibrous hamartoma cells. METHODS Fibroblast-like cells were obtained from enzymatically dissociated fibrous hamartomas of 11 patients ...

Angio eccrine hamartoma (EAH) is a rare, benign tumoral lesion composed of glands and vascular structures in the mid dermis. We report on two observations Dakar. Observation 1: A four-month-old infant was seen for an erythematous plaque, rounded, with smooth surface, asymptomatic, localized to right thigh, evolving three months. The clinical appearance suggested spitz tumour. Cutaneous histolog...

Fibrous hamartoma of infancy is a rare, benign soft tissue tumor that typically occurs within the first two years life. The histogenesis unclear. It most commonly found in axilla, shoulder, inguinal region, and chest wall usually solitary malformation located subcutaneous or reticular dermis. Local recurrence uncommon treatment largely successful by local excision. clinical course prognosis exc...

BACKGROUND Fibroma, neurofibroma, and papilloma are the most commonly encountered benign lesions in the nasopharynx. Hamartomas are non-neoplastic overgrowth of mature/differentiated tissue indigenous to the specific part of the body in which they develop. Most hamartomas are located in the liver, spleen, lungs, and pancreas. However, nasopharyngeal hamartoma is rare. CASE PRESENTATION We des...

A 51-year-old woman presented with a rare completely intradural and extramedullary spinal ganglioneuroma associated with multiple hamartoma syndrome and manifesting as complaints of neck pain and dizziness persisting for 8 months. Magnetic resonance imaging of the spinal cord revealed an intradural extramedullary lesion at the C1 level. She underwent right suboccipital craniectomy and C1-2 hemi...

Despite of the fact that the vulva contains a high density of apocrine and anogenital mammary glands in addition to eccrine glands and folliculosebaceous units, the benign vulvar adnexal tumours are rare. Though the varied clinical presentation and diverse histopathological spectrum of vulvar neoplasms has amazed the pathologists, only few studies have been reported in literature. The present f...

Splenic hamartoma (or splenoma) is a rare, benign, vascular tumor, often incidentally found at imaging, surgery or autopsy. Albeit usually asymptomatic and rare in children, when it occurs in the pediatric population it is more commonly symptomatic. We report a case of a 15-year-old girl with iron-deficiency anemia and beta-thalassemia, who had a large (10 × 8 × 7 cm) splenic lesion with calcif...

A 65-year-old woman had been followed up for a hamartoma-like mass in the right upper lobe of the lung since 1995. A follow-up CT scan showed an increase in the size of the lesion and a new lesion next to the old mass, which was highly suspected to be lung cancer. A right upper lobectomy was thus performed in May 2000. The hamartoma penetrated the visceral pleura, and adhered to the mediastinal...

To our knowledge, this is the first report of hypogonadotropic hypogonadism, or growth hormone deficiency, in a patient without non-Pallister-Hall syndrome who had hypothalamic hamartoma diagnosed on the basis of MR imaging and MR spectroscopy findings. On short-TE proton MR spectra, the N-acetylaspartate concentration in the hamartoma was lower than that in the thalamus but similar to that in ...