Submit Manuscript | http://medcraveonline.com followed in patients with thyroid nodules and specifically the widespread adoption and use of fine needle aspiration [4]. As a result of the “over diagnosis” of these small indolent tumors, the excellent prognosis and clinical outcome of these patients and a non-negligible percentage of surgical complications, there is growing evidence to suggest ac...

Thyroid cancer is the most common of the endocrine malignancies and it represents <1% of all human tumors. The annual incidence of thyroid cancer varies considerably by geographic area, age and sex. A recent review reported an overall incidence of all types of thyroid cancer in the USA of 7.7 per 100 000 person-years, with rates of 11.3 per 100 000 woman-years and 4.1 per 100 000 man-years [1]....

Recently we identified a molecular basis for differentiating benign and malignant follicular thyroid tumors. The purpose of these studies was to determine whether molecular analysis can be used to differentiate papillary thyroid carcinomas from benign thyroid nodules. Gene expression patterns of 14 papillary thyroid carcinomas and 21 benign tumors were analyzed by oligonucleotide array analysis...

Objective: The objectives were to evaluate fine needle aspiration cytology results of 39 pediatric patients, and the pathologies that cause childhood thyroid nodules, and to review the literature on the subject. Material and Method: Thyroid fine needle aspiration cytology results of 39 pediatric patients were retrospectively reviewed. Associated diseases, thyroid functions, anti-thyroid antibod...

Background: Thyroid cancer is the most frequently occurring of endocrine organs. From past few decades, prevalence thyroid carcinoma increasing generally and this has aroused great public concern.Papillary primarily responsible for high prevalence.The cases other types malignancies have remained stable over time. Aim: To analyze our institution-based trends in histopathological characteristics ...

Antipeptide antibodies raised against the carboxyl-terminal region of the human sodium/iodide (Na+/I-) symporter (hNIS) were used to investigate by immunohistochemistry the presence and distribution of the hNIS protein in normal thyroid tissues, in some pathological nonneoplastic thyroid tissues, and in different histotypes of thyroid neoplasms. In normal thyroid tissue, staining of hNIS protei...

hbme-l is an antimesothelial monoclonal antibody that recognizes an unknown antigen on microvilli of mesothelial cells. the antibody is only relatively specific for mesothelium and is used in the differential diagnosis of mesothelioma and adenocarcinoma within the context of an appropriate immuno-histochemical panel. hbme-l has also been reported to strongly and uniformly stain papillary and fo...

OBJECTIVE Endothelin-1 (ET-1) may play a role in carcinogenesis. ET-1 axis is overexpressed in thyroid carcinoma. We investigated the expression and the production of ET-1 by thyroid cancer cells as well as the effect of ET-1 receptor antagonism on cell proliferation. DESIGN Human papillary and follicular thyroid carcinoma cell lines were cultured. MEASUREMENTS (i) Prepro-ET-1, ET-1 recepto...

HLA class II expressing thyroid follicular cells are found not only in classical thyroid autoimmune diseases, such as Graves' disease, but also in presumably nonautoimmune thyroid disorders such as nontoxic goiter. In this study the immunostimulatory function of the HLA class II expressing thyroid follicular cells derived from patients with nontoxic goiter and with Graves' disease was compared ...

Background: Noninvasive Follicular Thyroid Neoplasm (NIFTP), Well differantiated thyroid tumor with uncertain malignity potential (WDT-UMP), follicular (FT-UMP), and Hurtle cell neoplasia (HCN-UMP) have been included in the classification of tumors by WHO, incidence cancer increasing every passing year. There is no consensus regarding follow-up treatment processes these tumors. Our study aims t...