Puberty is frequently delayed in adolescent patients with chronic renal failure, due to temporarily insufficient hypothalamo-pituitary stimulation of the gonads. In these patients, basal levels of gonadotropins are normal or slightly elevated due to increased plasma half-life of luteinizing hormone (LH) and follicle stimulating hormone (FSH) [1]. However, the response to gonadotropin releasing ...

Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis. This review examines the regulation and function of these cell during fetal and post-natal development. Fetal Leydig cells are sensitive to both luteinising hormone (LH) and adrenocorticotrophic hormone (ACTH) but Leydig cell f...

background: poor ovarian response phenomenon has been observed in some of the in vitro fertilization-embryo transfer patients. some investigations found that follicle stimulating hormone receptor (fshr) gene plays a role in the process, but no direct evidence shows the correlation between genotypes of fshr and ovarian response. objective: exploring the molecular mechanism behind the mutation of...

The aim of this study was to determine if follicle stimulating hormone receptor and luteinizing hormone receptor (FSH-R and LH-R) expression is altered on granulosa cells (GC) of women with low oestradiol responses to FSH. Cells were obtained from mature follicles (>17 mm) following controlled ovarian stimulation. For comparison, chinese hamster ovary (CHO) cells transfected with FSH-R or LH-R ...

Follicle stimulating hormone (FSH) is a glycoprotein hormone with subunitsαandβ, and is required for gamete development. Differential glycosylation may produce diglycosylated FSH with higher biological activity, and is suspected to be generated via the action of oligosaccharyltransferase(OST) isoforms. Signal peptide hydrophobicity of α and β maycontribute to selective usage of OST, and hence m...

756 VOL 57, NO 11 / NOVEMBER 2008 THE JOURNAL OF FAMILY PRACTICE FAST TRACK Experts recommend a repeat morning testosterone level, plus testing levels of FSH, LH, and prolactin to evaluate the cause of low testosterone Obtain a repeat morning testosterone level, as well as levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin to help understand the cause of low t...

Objective: Surgical removal of endometriomas, even if performed in experienced hands, leads to a decrease ovarian reserve varying degrees depending on age. This study was designed determine the pre- and post-surgical changes markers patients who underwent endometrioma cystectomy. Methods: Gözde Akademi Hospital gynecology outpatient clinic with diagnosis symptomatic included study. Fourteen nor...

On November 19, 2022, the production facility manufacturing of biotechnological substances for women's reproductive health was opened at Zavod Medsintez LLC in Novouralsk. In 2018, LLC, together with IVFarma has launched industrial-scale operation first Russian follicle-stimulating hormone (FSH) drug Primapur® infertility treatment within framework vitro fertilization (IVF) protocol. shows high...

Background The aim of this study was to evaluate the efficacy and safety of a recombinant human follicle stimulating hormone (r-FSH) low-dose step-up regimen for controlled ovarian hyperstimulation in patients undergoing ovulation induction (OI) with intrauterine insemination (IUI). MaterialsAndMethods The study was conducted in the Department of Obstetrics and Gynecology, Far Eastern Memorial ...

Age at pubertal onset varies substantially in healthy girls. Although genetic factors are responsible for more than half of the phenotypic variation, only a small part has been attributed to specific genetic polymorphisms identified so far. Follicle-stimulating hormone (FSH) stimulates ovarian follicle maturation and estradiol synthesis which is responsible for breast development. We assessed t...