Folate intake is strongly influenced by various methods of cooking that can degrade the natural forms of the vitamin in foods. The aim of the present study was to determine the effect of different cooking methods on folate retention in various foods that contribute to folate intake in the UK diet. Typical purchasing and cooking practices of representative food folate sources were determined fro...

The deposition of dietary folic acid (FA) into the chicken egg is likely regulated by its conversion to 5-methyltetrahydrofolate (5-MTHF), the predominant form of this vitamin in eggs (>80%). Supplementation of 5-MTHF in the laying hens′ diet may therefore enhance total egg folate concentrations. To this end, a study was conducted using equimolar concentration of either FA or 5-MTHF in diets fe...

It is only recently that folate deficiency has been implicated in the development of cancer. The mechanisms by which folate might protect against cancer are not clear but may relate to its role in DNA methylation and DNA synthesis. All case-control, cohort and intervention trials reported in English, French, or German, on folate intake or blood levels in relation to the risk of colorectal, brea...

I T WAS SHOWN by Toennies et a!.1 that most of the blood folate is within the erythrocytes. The erythrocyte folate level may be reduced in either folate or vitamin B12 deficiency,25 and it can be used as an index of the folate content of body tissues.4 The present paper reports that in iron deficiency anemia there are abnormalities in distribution of folate between plasma and erythrocytes which...

Folate coenzymes supply the activated one-carbon units required in nucleic acid biosynthesis, mitochondrial and chloroplast protein biosynthesis, amino acid metabolism, methyl group biogenesis, and vitamin metabolism. Because of its central role in purine and thymidylate biosynthesis, folate-mediated one-carbon metabolism has been the target of many anticancer drug therapies. This review is a s...

Taking folate before conception and then for the first three months of pregnancy reduces the risk of recurrence of neural tube defects, and fortification of food has been proposed. The effects of long term exposure to high concentrations of supplemental folate are unknown, and antimetabolite effects are theoretically possible. Data on the long term effects of increased folate intake in pregnanc...

Folate stimulation is known to enhance Dictyostelium discoideum differentiation. During early differentiation, D. discoideum cells possess two classes of folate receptors which can be distinguished by their difference in specificity (R. J. W. de Wit, FEBS Lett. 150, 445-448, 1982). We investigated the type of receptor by which folate affects cell differentiation. Two independently regulated dev...

RESULTS: The limit of quantification was 0.25 nmol/L, and the assay was linear in the range 0.25–96 nmol/L, which includes the 99.75 percentile for serum folate concentrations in healthy blood donors. Withinand between-day imprecision was 5%. We detected no residual folate in serum samples after sample preparation. Folate concentrations in fresh serum samples obtained with the pABG assay and wi...

Aim: The purpose of this study was to see how folate and + zinc treatment affected endocrine markers sperm properties in sub fertile males. Methods: methodical research addition meta-analysis carried out. From 1969 May 2020, databases were searched by Medline, Scopus, Google scholar, Persian have been examined that used the set pertinent keywords comprising "folate or folic acid AND (infertilit...