Human immunodeficiency virus type 1 protease (HIV-1 PR) is an essential enzyme for the replication cycle of HIV. HIV-1 PR inhibitors have been extensively investigated as anti-AIDS drugs. In the presence of HIV-1 protease inhibitors, the virion is unable to mature. Natural compounds are important sources of drugs. The present investigation concentrates on discovering anti-HIV compounds that are...

Triterpenoids extracted from Cimicifuga foetida have been reported to inhibit cancer by inducing cell cycle arrest and apoptosis. In this study, KHF16 (24-acetylisodahurinol-3-O-β-D-xylopyranoside), a cycloartane triterpenoid isolated from the rhizomes of C. foetida, showed potent anti-cancer activity in multiple ERα/PR/HER2 triple-negative breast cancer (TNBC) cell lines. KHF16 significantly i...

Rubiales D. (2014): Legume breeding for broomrape resistance. Czech J. Genet. Plant Breed., 50: 144–150. Legume cultivation is hampered in Mediterranean regions by the occurrence of the root parasitic weeds Orobanche crenata (crenate broomrape) and Orobanche foetida (foetida broomrape). Strategies of control have been developed but only marginal successes have been achieved. Most control method...

Emergence of drug resistance amongst clinical isolates of bacteria and fungi has led to the need of search for alternate drug candidates. Medicinal plants are a source of antimicrobial agents and some of which have been used for centuries by tribes in Assam. In this study, extracts of six medicinal plants namely Cissus quadrangularis L., Moringa oleifera L., Ziziphus jujuba M., Cassia fistula L...