Flavin-containing monooxygenases (FMOs) are important for the disposition of many therapeutics, environmental toxicants, and nutrients. FMO3, the major adult hepatic FMO enzyme, exhibits significant interindividual variation. Eighteen FMO3 single-nucleotide polymorphism (SNP) frequencies were determined in 202 Hispanics (Mexican descent), 201 African Americans, and 200 non-Latino whites. Using ...

Flavin-containing monooxygenases (FMOs) 1-4 oxidize methionine (Met) to methionine sulfoxide (MetO). FMO3, the primary isoform expressed in adult human liver, has the lowest Km and favors methionine-d-sulfoxide (Met-d-O) formation over methionine-l-sulfoxide. Because female mice, but not males, also express FMO3 in liver, levels of Met and its major metabolites were determined in male or female...

Flavin-containing monooxygenases (FMOs) are important in detoxication but generally are considered not to be inducible by xenobiotics. Our recent microarray studies revealed induction of FMO2 and FMO3 mRNAs by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver of mice with wild-type aryl hydrocarbon receptor (AHR) but not in Ahr-null mice. The aim of the present study was to delineate mechanis...

We perform a spectral energy distribution fitting analysis on COSMOS photometric sample covering the ultra-violet up to far-infrared wavelengths and including emission lines from Fiber Multi-Object Spectrograph survey. The consists of 182 objects with H α [OIII] λ 5007 line measurements lying in redshift range 1.40 < z 1.68. obtain robust estimates stellar mass star-formation rate spanning o...

Abstract We present a detailed study of the partial rest-optical ( ? obs ? 3600–5600 Å) spectra N = 767 star-forming galaxies at 0.6 < z 1.0 from Large Early Galaxy Astrophysics Census (LEGA-C). compare this sample with low-redshift ? 0) Sloan Digital Sky Survey (SDSS), intermediate-redshift 1.6) Fiber Multi-Object Spectrograph (FMOS)-COSMOS Survey, and high-redshift 2) Keck Baryonic Structu...

The baculovirus expression vector system was used to overexpress human FMO3 in insect cells for catalytic, structural, and immunochemical studies. Membranes prepared from infected Trichoplusia ni cell suspensions catalyzed NADPH-dependent metabolism of methyl p-tolyl sulfide at rates 20 times faster than those obtained with detergent-solubilized human liver microsomes. Sulfoxidation of the meth...

A novel sequence for reversible second-order nonlinear optical (NLO) molecular switching with protonation/deprotonation has been achieved and tuned as well. The NLO switching with first hyperpolarizabilities (beta(0)) as low as 14 x 10(-30) esu (Off-phase) and as large as 1189 x 10(-30) esu (On-phase) have been computed by using density functional theory (DFT). Remarkably large differences betw...

We report in this study the influence of green solvents (water and DMSO) effect structural parameters, frontier molecular orbital's (FMO's) electrostatic potential surface analysis (MEPS) 1-ethylpiperazine-1,4-diium bis(hydrogenoxalate) (1EPBH) compound by means DFT method. The has been examined signal-crystal X-ray diffraction (XRD), infrared (IR) nuclear magnetic resonance (NMR) spectroscopy....

BACKGROUND B-Lactam antibiotics are still the most common group of chemotherapeutic drugs that are used in the treatment of bacterial infections. However, due to their chemical instability the potential to apply them as oral pharmacotherapeutics is often limited and so it is vital to employ suitable non-destructive analytical methods. Hence, in order to analyze such labile drugs as β-lactam ana...

Multiple GSH adducts of the oxidative products of nomifensine (M1-M9) in human hepatocytes and liver microsomes have been identified recently. The current study reports three new types of monooxygenated metabolites of nomifensine identified in human liver microsomes: C-linked hydroxylated metabolites with modifications at the A ring (H1 and H4), an N-hydroxylamine (H6), and nomifensine N-oxides...