A novel selective and substrate-dependent synthetic protocol has been developed towards the synthesis of various fluorine-containing, highly functionalized cycloalkane derivatives. The method involves the stereoselective epoxidation of some unsaturated cyclic β-amino acid derivatives as model compounds, followed by a regioselective fluoride opening of oxiranes under various conditions with Deox...

The generation of a small and representative library of 3,5,8-trisubstituted coumarins (21 compounds, 7 families, 3 groups) is described. The library was built from the corresponding propargyl vinyl ethers and three different 1,3-dicarbonyl derivatives using a one-pot coupled domino strategy. These coumarins constitute a novel chemotype defined by the presence of a chemical handle in the pyrano...

Little is known about the effect of fluorides on bacteria. In large concentrations inorganic and organic fluoride compounds inhibit growth. Fluorine is not known to be an essential trace element for bacteria, fungi, or algae. Recently Davis and Dubos (1947) have shown that fluoride inhibits the action of a lipase on "tween 80" in concentrations that do not affect the growth of Mycobacterium tub...

Difficulties associated with MXene fabrication typified by an environmentally hazardous fluorine-based etching process followed delamination and fluorine reduction steps create obstacles against the expansion of this outstanding material its application in air purification. Herein, we demonstrate a one-step hydrothermal that involves alkali (NaOH)-assisted aluminum presence delaminating agent (...

There has been an increasing importance of drug-resistant pathogens in clinical microbiological and antibacterial research. Indoles and hydrazone-type compounds constitute important classes of compounds in the search for effective agents against multidrug-resistant microbial infections. In this study a series of 1-methylindole-3-carboxaldehyde hydrazone derivatives were evaluated for their in v...

Magnesium slag is a valuable resource when proper disposal and utilization are adopted. The main pollution of magnesium caused dust fluorine pollution. Formation mechanism fine investicated. Alike steel slag, phase transition dicalcium silicate in around 500 °C brings volume expansion, which causes the disintegration powdering slag. Chamical stabilization experiments were carried out. effects p...

Interactions between fluorine (as F) and aluminum (as Al) have recently attracted much attention following reports of their possible involvement in Alzheimer’s disease (AD). An inverse correlation has been demonstrated between the incidence and severity of AD and the level of fluorine in drinking water.1-4 Aluminum has long since been implicated in the etiopathology of AD, and neurotoxicity stu...

Implanted fluorine is observed to behave unusually in silicon, manifesting apparent uphill diffusion and reducing diffusion and enhancing activation of boron. In order to investigate fluorine behavior, we calculate the energy of fluorine defect structures in the framework of density functional theory. In addition to identifying the ground-state configuration and diffusion migration barrier of a...

Substitution reactions of 1,2-difluoro-4,5-dinitrobenzene were explored in dimethylformamide alone and with KOH/H 2 O, Hünig’s base or Et 3 N Me NHCl/Et EtOH. The fluorine atoms always displaced preference to the nitro groups. Three compounds prepared from these studies characterised by X-ray single crystal structure determinations.