Human membrane bound O-acyltransferase domain-containing 7 (MBOAT7), also known as lysophosphatidylinositol acyltransferase 1 (LPIAT1), is an enzyme involved in the acyl-chain remodeling of phospholipids via Lands' cycle. The MBOAT7 rs641738 variant has been associated with entire spectrum fatty liver disease (FLD) and neurodevelopmental disorders, but exact enzymatic activity catalytic site pr...

Activator protein 1 (AP-1) is a dimeric transcription factor with important roles in specifying genetic and cellular programs. AP-1 refers to a collection of DNAbinding homoand heterodimers formed by members of the JUN (c-Jun, JunB, and JunD) and FOS (c-Fos, FosB, Fra-1, and Fra-2) families, as well as ATF and MAF proteins. AP-1 dimers recognize similar and specific sequence elements in the pro...

The combination of lanthanide ions and nitronyl nitroxide radicals resulted in four new Ln-radical one-dimensional compounds, namely, [Ln(hfac)3{NIT-Ph(OMe)2}]n(Ln(III) = Sm (1), Eu (2), Gd (3), Dy (4); hfac = hexafluoroacetylacetonate; NIT-Ph(OMe)2 = 2-(2',4'-dimethoxyphenyl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazolyl-1-oxyl-3-oxide). The four complexes were found to be isomorphous and exhi...

Glycosylation is an essential posttranslational modification observed in the living proteome. profiles glycoproteins can change commonly diseases such as cancer. Identifying these changes crucial discovering new biomarkers for early diagnosis of One main steps N-glycan analysis to release N-glycans from by specific enzymes. The study compares common denaturing agent combinations used methods. I...

Background: We analyzed local regional recurrence patterns of thoracic esophageal carcinoma after three-field lymph node dissection (3-FLD) with and without postoperative radiotherapy, assessed the radiation value for control. Methods: The study reviewed 239 recurrences squamous cell 3-FLD from 2010 to 2018 in our hospital, retrospectively, compared between sur...

In the learning and recognition methods we introduced till now, we have not made strong assumptions about the data: Nearest neighbor, SVM, distance metric learning, normalization and decision trees do not explicitly assuming distributional properties of the data; PCA and FLD are optimal solutions under certain data assumptions, but they work well in many other situations too; parametric probabi...

The enhanced mechanical properties obtained by refining the grain size down to ultrafine-grained (UFG) regime have attracted considerable attention in recent years. severe plastic deformation (SPD) techniques allow obtaining materials. Different SPD permit processing sheet shape materials such as repetitive corrugation and straightening (RCS) accumulative roll bonding (ARB). In this study, form...