We describe a technique for estimating control parameters for a plucked string synthesis model using a genetic algorithm. The model has been intensively used for sound synthesis of various string instruments but the fine tuning of the parameters has been carried out with a semiautomatic method that requires some hand adjustment with human listening. An automated method for extracting the parame...

In Brazil, decades of dengue vector control using organophosphates and pyrethroids have led to dissemination of resistance. Although these insecticides have been employed for decades against Aedes aegypti in the country, knowledge of the impact of temephos resistance on vector viability is limited. We evaluated several fitness parameters in two Brazilian Ae. aegypti populations, both classified...

Control analysis can be used to try to understand why (quantitatively) systems are the way that they are, from rate constants within proteins to the relative amount of different tissues in organisms. Many biological parameters appear to be optimized to maximize rates under the constraint of minimizing space utilization. For any biological process with multiple steps that compete for control in ...

BACKGROUND The extraordinary diversity characterizing the antibody repertoire is generated by both evolution and lymphocyte development. Much of this diversity is due to the existence of immunoglobulin (Ig) variable region gene segment libraries, which were diversified during evolution and, in higher vertebrates, are used in generating the combinatorial diversity of antibody genes. The aim of t...

Aedes aegypti dispersion is the major reason for the increase in dengue transmission in South America. In Brazil, control of this mosquito strongly relies on the use of pyrethroids and organophosphates against adults and larvae, respectively. In consequence, many Ae. aegypti field populations are resistant to these compounds. Resistance has a significant adaptive value in the presence of insect...

In this paper, a meta-optimization algorithm, based on Local Unimodal Sampling (LUS), has been applied to tune selected parameters of QuantumInspired Evolutionary Algorithm for numerical optimization problems coded in real numbers. Tuning of the following two parameters has been considered: crossover rate and contraction factor. Performance landscapes of the algorithm meta-fitness have been app...

The fitness landscape in sequence space determines the process of biomolecular evolution. To plot the fitness landscape of protein function, we carried out in vitro molecular evolution beginning with a defective fd phage carrying a random polypeptide of 139 amino acids in place of the g3p minor coat protein D2 domain, which is essential for phage infection. After 20 cycles of random substitutio...

S1 Experimental methods 1 S1.1 Strains . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 S1.2 Fitness costs of amino acid overproduction due to feedback resistance . . . . . . . . . . . . . 2 S1.3 Radial expansion velocities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 S1.4 Determination of yeast colony growth para...

Metastability is a common phenomenon. Many evolutionary processes, both natural and artificial, alternate between periods of stasis and brief periods of rapid change in their behavior. In this paper an analytical model for the dynamics of a mutation-only genetic algorithm (GA) is introduced that identifies a new and general mechanism causing metastability in evolutionary dynamics. The GA’s popu...