Accumulation of mitochondrial DNA (mtDNA) mutations has been implicated in a wide range of human pathologies, including neurodegenerative diseases, sarcopenia, and the aging process itself. In cells, mtDNA molecules are constantly turned over (i.e. replicated and degraded) and are also exchanged among mitochondria during the fusion and fission of these organelles. While the expansion of a mutan...

Upon exocytosis, fused vesicles must be retrieved for recycling. One route of retrieval is to generate endosome-like structures, from which small vesicles bud off. Endosome-like structures are widely thought to be generated slowly ( approximately 1 min) from the plasma membrane, a process called bulk endocytosis. Although the concept of bulk endocytosis seems established, the kinetic evidence s...

The single-particle aspects of nuclear fission theories are investigated. The liquid drop model is shown to be essentially equivalent to an independent particle model with the requirement that particles occupy the lowest orbits. The consequences of relaxing this requirement are pursued and are shown to be significant. A natural framework is provided in which the mass asymmetry of fission arises...

A new experimental approach is introduced to investigate the relaxation of the nuclear deformation degrees of freedom. Highly excited fissioning systems with compact shapes and low angular momenta are produced in peripheral relativistic heavy-ion collisions. Both fission fragments are identified in atomic number. Fission cross sections and fission-fragment element distributions are determined a...

An enhanced comprehension of the fission process is essential to our understanding nuclear dynamics as well other phenomena such stellar nucleosynthesis and reactor spectra that probe fundamental physics. In this paper authors take an important step toward role angular momentum in fission.

Mitochondrial function is intimately linked to cellular survival, growth, and death. Mitochondria not only generate ATP from oxidative phosphorylation, but also mediate intracellular calcium buffering, generation of reactive oxygen species (ROS), and apoptosis. Electron leakage from the electron transport chain, especially from damaged or depolarized mitochondria, can generate excess free radic...

The present work investigates an appropriate way to calculate the 1700 atomic density changes in the reactor operations. To automate this procedure, a computer program has been designed by C#. This program suggests a way to solve this problem which is based on the solution system of differential equations (Bitman) that it is designed according to Runge-Kutta Fehlberg method. The designed softwa...

In fission yeast, we propose that the division plane may be positioned by the position of the premitotic nucleus, perhaps by a signal emanating from the nucleus. Gene products involved in the assembly of the ring and its temporal and spatial controls are beginning to be characterized. Some of these, such as mid1p, may be involved in signals that position the division site. In animal cells, the ...

A two-step reaction scheme for the production of extremely neutron-rich radioactive beams, fission followed by cold fragmentation, is considered. The cross sections of the second step, the cold fragmentation of neutron-rich fission fragments, are estimated with different computer codes. Discrepancies between an empirical systematics and nuclear-reaction codes are found. PACS: 25.40.Sc Spallatio...