THE FETUS DEVELOPS IN HYPOXIA (3–5% O2), which is essential for the vasculature. Vascular growth, in turn, is required for lung development (11). For these processes, the essential role of the transcription factor hypoxia-inducible factor (HIF) is increasingly apparent. Genetic inactivation of either HIF-1 or -2 in mice leads to fetal or neonatal lethality because of major developmental defects...

Introduction: CD19 is an established target of multiple B-cell lymphoma therapies. Blockade CD47, a macrophage immune checkpoint inhibitory ligand, induces tumor-cell phagocytosis. TG-1801 CD19/CD47 bispecific antibody designed to selectively block CD47 on CD19+ cells, while retaining functional IgG1 Fc domain. Herein we report updated results from the FIH study. Methods: The primary objectives...