Abstract In flood frequency analysis (FFA), annual maximum (AM) model is widely adopted in practice due to its straightforward sampling process. However, AM has been criticized for limited flexibility. FFA using peaks-over-threshold (POT) an alternative model, which offers several theoretical advantages; however, this currently underemployed internationally. This study aims bridge the current k...

BACKGROUND Metabolic modulators that enhance myocardial glucose metabolism by inhibiting free fatty acid (FFA) metabolism may improve cardiac function in heart failure patients. We studied the effect of acute FFA withdrawal on cardiac function in patients with heart failure caused by idiopathic dilated cardiomyopathy (IDCM). METHODS AND RESULTS Eighteen fasting nondiabetic patients with IDCM ...

Assessment of free fatty acid (FFA) concentration and isotopic enrichment is useful for studies of FFA kinetics in vivo. A new procedure to recover the major FFA from plasma for concentration and isotopic enrichment measurements is described and validated. The procedure involves extraction of plasma lipids with hexane, methylation with iodomethane (CH(3)I) to form fatty acid methyl esters (FAME...

We have shown that insulin controls endogenous glucose production (EGP) indirectly, via suppression of adipocyte lipolysis. Free fatty acids (FFA) and EGP are suppressed proportionately, and when the decline in FFA is prevented during insulin infusion, suppression of EGP is also prevented. The present study tested the hypothesis that suppression of lipolysis under conditions of constant insulin...

It is well known that morphine produces hyperglycemia in some laboratory animals such as rats, dogs and so on (1) by inducing the release of catecholamine from the adrenal medulla (2). As catecholamine raises the level of free fatty acids (FFA) in blood as well as that of glucose (3), there would be a possibility that morphine also raises the level of FFA in blood. On the other hand the changes...

Triiodothyronine (T(3)) exerts direct action on myocardial oxygen consumption (MVO(2)), although its immediate effects on substrate metabolism have not been elucidated. The hypothesis, that T(3) regulates substrate selection and flux, was tested in isovolumic rat hearts under four conditions: control, T(3) (10 nM), epinephrine (Epi), and T(3) and Epi (TE). Hearts were perfused with [1,3-(13)C]a...

Adipose tissue lipolysis and fatty acid reesterification by liver and adipose tissue were investigated in rats fasted for 15 h under basal and calorigenic conditions. The fatty acid flux initiated by adipose fat lipolysis in the fasted rat is mostly futile and is characterized by reesterification of 57% of lipolyzed free fatty acid (FFA) back into adipose triglycerides (TG). About two-thirds of...

Two of the most robust markers for "special" face processing are the behavioral face-inversion effect (FIE)-the disproportionate drop in recognition of upside-down (inverted) stimuli relative to upright faces-and the face-selective fMRI response in the fusiform face area (FFA). However, the relationship between these two face-selective markers is unknown. Here we report that the behavioral FIE ...

aerobic conditions, it is imperative that such observations be verified and extended in the living animal. To our knowledge, there has been no report of any direct measurement of tumor FFA oxidation in vivo. The only indirect estimate of FFA oxidation by Ehrlich ascites carci noma in vivo is that reported by Mermier and Baker (22) using [9,10-3H]palmitate complexed to serum albumin. Ac cording ...