Moringa leaves are known as herbs that have many properties. The study aimed to analyzed moringa leaf extract against tissue histology, serum protein levels, fetal conditions at birth from distended mice with malnutrition. The research design was a pretest post test control group design using 28 distended mice with ...

Overexpression of the conserved Ca(2+)-binding proteins calreticulin and calsequestrin impairs cardiac function, leading to premature death. Calreticulin is vital for embryonic development, but also impairs glucocorticoid action. Glucocorticoid overexposure during late fetal life causes intra-uterine growth retardation and programmed hypertension in adulthood. To determine whether intra-uterine...

AIM To understand the molecular mechanism of esophageal cancer development and provide molecular markers for screening high-risk populations and early diagnosis. METHODS Two-dimensional electrophoresis combined with mass spectrometry were adopted to screen differentially expressed proteins in nine cases of fetal esophageal epithelium, eight cases of esophageal cancer, and eight cases of tumor...

Protein SAA is a serum protein related to the major constituent of secondary amyloid fibrils, protein AA, and has been suggested to be a precursor of the amyloid protein AA. In the present study, the origin of SAA was investigated by studying human fetal tissues and cultured human fetal fibroblasts with the indirect immunofluorescence technique. Anti-SAA antibodies reacted strongly with culture...

Undernutrition in fetal life programmes risk of obesity and the metabolic syndrome in adult life. Rat studies indicate that exposure to a maternal low-protein diet throughout fetal life establishes a preference for high-fat foods. The present study aimed to assess the effect of low protein exposure during discrete 7-day periods of gestation upon feeding behaviour (full gestation 22 days). Pregn...

Epidemiological studies have indicated that malnutrition during early life may programme chronic degenerative disease in adulthood. In an animal model of fetal malnutrition, rats received an isoenergetic, low-protein (LP) diet during gestation. This reduced fetal beta-cell proliferation and insulin secretion. Supplementation during gestation with taurine prevented these alterations. Since prote...

the umbilical vein (uv) has a non pulsating and even pattern in normal fetuses. pulsation of uv has been described in severely growth restricted fetuses with chronic hypoxia. we wanted to see whether uv pulsations could also be seen in fetuses with heart deceleration during labor, as an adjunctive measure to assess the intra partum hypoxia. in a prospective study doppler examination was perform...

mother's mental health status during pregnancy has important effects on fetal growth and development. however, there are few studies concerning association of maternal depression and biophysical profile (bpp) of the fetus. we performed this research to know if maternal depression has any association with fetal bpp score. for measuring depression, farsi version of patient health questionnaire-9 ...

Suboptimal developmental environments program offspring to lifelong metabolic problems. The aim of this study was to determine the impact of protein restriction in pregnancy on maternal liver lipid metabolism at 19 days of gestation (dG) and its effect on fetal brain development. Control (C) and restricted (R) mothers were fed with isocaloric diets containing 20 and 10% of casein. At 19 dG, mat...

The present study tests the hypothesis that age-dependent increases in endothelial vasodilator capacity are due to maturational increases in endothelial NO synthesis and release. Intact 4-cm carotid artery segments taken from term fetal lambs and non-pregnant adult sheep were perfused using a closed system that enabled independent control of flow and inflow pressure, and facilitated complete re...