Fentanyl decreases clearance of midazolam administered i.v., but the mechanism remains unclear. To elucidate this mechanism, we have investigated the effect of fentanyl on metabolism of midazolam using human hepatic microsomes and recombinant cytochrome P450 isoforms (n = 6). Midazolam was metabolized to l'-hydroxymidazolam (l'-OH MDZ) by human hepatic microsomes, with a Michaelis-Menten consta...

In a randomized, double-blind study of 39 mothers in labour, we have compared a loading dose of 0.5% bupivacaine 6.0 ml and fentanyl 100 micrograms given extradurally, followed by an infusion of 0.08% bupivacaine 15 ml h-1 plus fentanyl 37.5 micrograms h-1, with a loading dose of 0.5% bupivacaine 6.0 ml and saline 2.0 ml, followed by an extradural infusion of 0.08% bupivacaine alone, per hour. ...

the present study was designed to assess the efficacy of fentanyl and pancuronium combined with dilute lidocaine solution for axillary block. onehundred adult patients undergoing upper limb surgery were randomly allocated to receive either 0.6 ml/kg of 1 % lidocaine (6 mg/kg) or 0.6 mllkg of 0.5% lidocaine (3 mg/kg) with 1 µg/kg of fentanyl and 0.5 mg of pancuronium. the onset of sensory and mo...

Sweden regulates new psychoactive substances, including fentanyl analogs, individually. This reactive scheduling procedure enabled the existence of a recreational market for unscheduled analogs sold from surface webshops. We measure interest in 24 named and impact scheduling. scraped posts threads on Swedish internet forum Flashback.org, 2012–2019. The sample consists with total 8761 posts. con...

BACKGROUND The purpose of this study was to assess the economic impact of the fentanyl buccal tablet for the management of breakthrough cancer pain (BTcP) in Spain. METHODS A 4-year budget impact model was developed for the period 2012-2015 for patients with BTcP from the perspective of the Spanish National Health System. BTcP products included in this model were rapid-onset opioids containin...

Background: One of the minor obstitrical procedures is dilation and curettage; pain usually occurs during it. Consequently, an anesthetic drug desires sufficient analgesia, brisk onset, recovery.
 Objective: To evaluate two groups combinations {midazolam 0.08mg/kg – ketamine (0.5mg/kg)} propofol with (1mg/kg) –fentanyl dose (1mcg /kg)}, in hemodynamic parameters, scoring recovery character...

Background: Fentanyl is intrathecally used as an adjuvant to bupivacaine in spinal anesthesia, as well as labor analgesia, and in day surgery. The aim of this study was to determine the separate neurotoxic effect of each drug using histological analysis. Methods: Rats (N = 39) received fentanyl at 0.12μl/g body weight (0.05, 0.5, and 1 mg/ml) or bupivacaine (5, 25, and 50 mg/ml) dissolved in sa...

Objective: Long term use of opioids and benzodiazepines are associated with important untoward effects. The α2 adrenergic agonist clonidine has sedative effects. Our goal was to study clonidine addition to total doses of fentanyl and midazolam and duration of ventilation in pediatric ICU (PICU). Methods: This randomized, double-blind, placebo-controlled trial was conducted in PICU of Mofi...