نتایج جستجو برای: female rat
تعداد نتایج: 535577 فیلتر نتایج به سال:
Background: Uterine stimulants are medications used to induce/augment labor, induce abortion, and prevent postpartum hemorrhage. Currently, available drugs carrying adverse effects, hence the present study is designed effect of Carica papaya raw fruits extract in comparison with oxytocin using vitro rat uterus preparations. Aims Objectives: Primary secondary aims were evaluate uterine stimulant...
Doolen, Suzanne, Diana N. Krause, and Sue P. Duckles. Estradiol modulates vascular response to melatonin in rat caudal artery. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1281–H1288, 1999.—The purpose of this study was to determine whether estrogen modulates the function of vascular melatonin receptors. We used the rat caudal artery and found that the contractile effects of melatonin were i...
It is well known that the incidence of urinary stones is higher in men than women. Although it is believed that the lower incidence of urinary stones in women is due to a protective effect of estrogen, the mechanisms remain unclear. To clarify the relation between female sex hormones and stone matrix protein, we examined the interaction of estrogen receptor-α (ERα), estrogen receptor-related re...
The development of zinc finger nuclease (ZFN) technology has enabled the genetic engineering of the rat genome. The ability to manipulate the rat genome has great promise to augment the utility of rats for biological and pharmacological studies. A Wistar Hannover rat model lacking the multidrug resistance protein Mdr1a P-glycoprotein (P-gp) was generated using a rat Mdr1a-specific ZFN. Mdr1a wa...
To investigate effects of high-fat diet (HFD) on body length, weight and depression-like behavior prenatal stress (PS) offspring rats. PS rat model was established by restraint stress. Sucrose preference forced swimming tests were performed. Moreover, the HFD growth in rats observed. Length male female HF group significantly longer than that control, but length PS+HF shorter group. Body higher ...
Sulfation appears to be an important pathway for the reversible inactivation of thyroid hormone during fetal development. The rat is an often used animal model to study the regulation of fetal thyroid hormone status. The present study was done to determine which sulfotransferases (SULTs) are important for iodothyronine sulfation in the rat, using radioactive T4, T3, rT3, and 3,3'-T2 as substrat...
بررسی دخالت گیرنده های nmda گلوتاماتی در ناحیه آمیگدال مرکزی در رفتارهای شبه اضطرابی ناشی از نیکوتین
هدف مطالعه حاضر بررسی دخالت گیرنده های nmda امیگدل مرکزی در اثرات شبه اضطرابی نیکوتین می باشد . رتهای تر ویستار کاتوله شده در امیگدال مرکزی در ماز مرتفع بعلاوه epm مورد تحقیق قرار گرفتند. تزریق درون صفاتی (i.p) نیکوتنی با دوزهای (o.6.o.8mg/kg)کاهش معنی داری درصد زمان سپری شده در بازوی باز (%oat) و درصد ورود به بازوی باز (oae%) را نشان داد ولی اثری بر فعالیت حرکتی نداشت که نشان دهنده پاسخ شبه اض...
چکیده: اسید آسکوربیک در بیشتر نواحی مغز پستانداران به خصوص هسته اکومبنس یافت می شود. مطالعات قبلی نشان داده است که اسید آسکوربیک موجب کاهش اضطراب می شود، لذا در تحقیق حاضر به بررسی نقش تزریق اسید آسکوربیک، بروموکریپتین و تزریق توأم آنها در پوسته هسته اکومبنس بر اضطراب موش های صحرایی نر به وسیله پلاس میز می پردازیم. در این مطالعه از 70 سر موش صحرایی نر از نژاد wistarدر محدوده ی وزنی 270-220 گ...
Ecteinascidin 743 (ET743, NSC648766) is a marine natural product with potent in vivo activity in human xenograft models. Hepatotoxicity was the most prominent toxicity in preclinical studies and was greater in female rats than in male rats. To assess the potential implications for human toxicities, the in vitro metabolism of ET743 was characterized using rat and human preparations. NADPH-depend...
background: the increase in the rate of infertility in women has prompted the need to search for plants with antifertility potentials. objective: the effect of administration of aqueous extract of cnidoscolous aconitifolius leaves for seven days on reproductive hormones of female wistar rats was investigated. materials and methods: sixty female albino rats were grouped into four (a, b, c and d)...
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