The bacterial endotoxin or lipopolysaccharide (LPS) leads to the extensive vascular endothelial cells (EC) injury under septic conditions. Guanine nucleotide exchange factor-H1 (GEF-H1)/ROCK signaling not only involved in LPS-induced overexpression of pro-inflammatory mediator in ECs but also implicated in LPS-induced endothelial hyper-permeability. However, the mechanisms behind LPS-induced GE...

Morokweng is a large, 145 Ma impact structure in the Northwest Province of South Africa. The impact origin of this structure and its melt rock has been confirmed by ample evidence of shock metamorphism in clasts within the melt rock and samples from granitoid basement below the melt body. The age of this structure is indistinguishable from the biostratigraphic age of the Jurassic-Cretaceous (J-...

In this paper, a Bayesian framework is used to infer HiRISE-equivalent rock density from CTX image features without needing to explicitly identify rocks. The statistical relationship between HiRISE rock density and CTX image features is modeled using Bayesian Networks. The model is enriched by including geological features—specifically, geomorphic units. The geomorphic units are identified by g...

Neutrophil-induced coronary microvascular barrier dysfunction is an important pathophysiological event in heart disease. Currently, the precise cellular and molecular mechanisms of neutrophil-induced microvascular leakage are not clear. The aim of this study was to test the hypothesis that rho kinase (ROCK) increases coronary venular permeability in association with elevated endothelial tension...

ub lis he d by M an ey P ub lis hi ng ( c) IO M C om m un ic at io ns L td A methodology developed to estimate with accuracy the instantaneous specific rock energy using corrected downthe-hole (DTH) drill monitoring data is presented. A specific rock energy profile can be generated for every hole, and thus a drilling site can be mapped for this index. A special data acquisition system was devel...

In the process of the highway tunnel construction, the stability and the reliability of tunnel rock is an important guarantee to ensure safety construction. Tunnel surrounding rock deformation monitoring is an important method for obtaining information on surrounding rock and controlling tunnel stability in the period of construction. Forecasting deformation of surrounding rock is the key to es...

CXCR4 is a chemokine receptor often found aberrantly expressed on metastatic tumor cells. To investigate CXCR4 signaling in tumor cell adhesion, we stably overexpressed CXCR4 in MCF7 breast tumor cells. Cell attachment assays demonstrate that stimulation of the receptor with its ligand, CXCL12, promotes adhesion of MCF7-CXCR4 cells to both extracellular matrix and endothelial ligands. To more c...

RhoE belongs to the Rho GTPase family, the members of which control actin cytoskeletal dynamics. RhoE induces stress fiber disassembly in a variety of cell types, whereas RhoA stimulates stress fiber assembly. The similarity of RhoE and RhoA sequences suggested that RhoE might compete with RhoA for interaction with its targets. Here, we show that RhoE binds ROCK I but none of the other RhoA tar...