Some individuals are resilient, whereas others succumb to despair in repeated stressful situations. The neurobiological mechanisms underlying such divergent behavioral responses remain unclear. Here, we employed an automated method for mapping neuronal activity in search of signatures of stress responses in the entire mouse brain. We used serial two-photon tomography to detect expression of c-F...

In this issue of PLoS Biology, Burger and colleagues make several important contributions to the discourse of sustainability science, recalling limits of human economic and population growth derived from macroecology and physical principles [1]. We agree with many of the points offered in their paper in this issue and with those in the paper by Brown and colleagues [2]. However, we also believe...

This study was designed to identify predictors of parental stress and psychological distress among parents of children with mental retardation in the United Arab Emirates. It examined the relative contributions of child characteristics, parents' sociodemographics, and family environment to parental stress and psychological distress. Participants were parents of 225 mentally retarded children, o...

BACKGROUND Milieu therapists' relationships with patients with severe mental illnesses are viewed as challenging. Elucidating vulnerability from their perspective in daily face-to-face encounters with patients might contribute to extending our knowledge about milieu therapists' vulnerability and the dynamics of the interaction between patients in mental health services and expertise in building...

Alzheimer disease is 1 of 5 leading causes of death in persons older than 65 years. The term suffering is used in all disciplines and a variety of contexts with no clear universal definition. Identifying dimensions and qualities (dimensional analysis) of the concept of suffering will assist in better understanding the concept and being able to apply it to science and practice. The objectives of...

I was pleased to see that Occupational Medicine thought it appropriate to publish an editorial on ethical publication [1]. It is important that the ethics of research and publication remain in the consciousness of occupational physicians. This is particularly so where they are actively involved in occupational medicine research and therefore the ethical treatment of workers who participate in s...

Background Opioid and dopamine systems play crucial roles in reward. Similarities and differences in the neural mechanisms of reward that are mediated by these 2 systems have remained largely unknown. Thus, in the present study, we investigated the differences in reward function in both µ-opioid receptor knockout mice and dopamine transporter knockout mice, important molecules in the opioid and...

Growing evidence indicates that there is a correlation between depression and inflammation. Administration of anti-tumor necrosis factor (TNF) agents for treatment of chronic inflammatory diseases, such as psoriasis, was associated with decreased depressive symptoms and increased quality of life in some clinical studies. The aim of the present study was to investigate the effects of chronic eta...

This intriguing article explored a challenging topic using a novel albeit somewhat controversial methodology. This commentary is made from the perspective of an applied sports psychology practitioner who has conducted qualitative research, with the primary focus on how this informs best practice in consulting with athletes. Newman et al. (2016) certainly raised questions for practitioners about...

International guidelines on schizophrenia and worldwide experts in psychiatry recommend and insist on monotherapy with an antipsychotic medication for schizophrenic patients. Studies about the clinical practice of these guidelines show that all over the world most schizophrenia patients receive two or more antipsychotics. Further more combinations with antidepressants, mood stabilizers or benzo...