PURPOSE To investigate whether genetic variants in inflammation-related genes are associated with increased risk of childhood-onset febrile seizures. METHOD Tagging single nucleotide polymorphisms (SNPs) from 19 inflammation-related candidate genes were identified and genotyped on the Sequenom platform in a sample of Caucasian childhood-onset febrile seizures cases (n=98) compared to ethnicit...

BACKGROUND Genetic epilepsy with febrile seizures plus (GEFS+) is a familial epilepsy syndrome with extremely variable expressivity. Mutations in 5 genes that raise susceptibility to GEFS+ have been discovered, but they account for only a small proportion of families. METHODS We identified a 4-generation family containing 15 affected individuals with a range of phenotypes in the GEFS+ spectru...

OBJECTIVE To study the role of iron deficiency as a risk factor for simple febrile seizures. DESIGN Case control study. SETTING Pediatric department of a tertiary care teaching hospital. PARTICIPANTS 154 cases and 154 controls were included in the study. Consecutive cases and concurrent controls were selected. Cases were children of age group 6 months to 3 years presenting with simple feb...

OBJECTIVES The aim of this study was to determine the association between iron status and febrile seizures in children aged 6 months to 5 years. METHODS This prospective case-control study enrolled 300 children who presented with febrile seizures (case group) and 200 children who presented with a febrile illness without seizures (control group) from March 2007 to January 2009. Hemoglobin, mea...

Febrile seizures are the most common seizure type in children (6 mo to 5 yr). The pathophysiology of febrile seizures is unknown. Current genetic studies show that some febrile seizures result from channelopathies. We have performed electrophysiological experiments in in vitro hippocampal slices to test a novel hypothesis that a disordered regulation of ionic homeostasis underlies the genesis o...

Febrile seizures are associated with increased brain temperature and are often resistant to treatments with antiepileptic drugs, such as carbamazepine and phenytoin, which are sodium channel blockers. Although they are clearly correlated with the hyperthermic condition, the precise cellular mechanisms of febrile seizures remain unclear. We performed patch-clamp recordings from pyramidal cells i...

TO THE EDITOR—“I am worried that my child will get this serious side effect if she is vaccinated” is a common concern raised by parents of infants and toddlers. Since vaccines are generally very safe, many of these concerns can be assuaged. However, a few vaccinated children will experience serious adverse events. While current vaccines are of major public health benefit, history has taught us ...

Severe myoclonic epilepsy of infancy (SMEI, also known as Dravet syndrome) and genetic epilepsy with febrile seizures plus (mild febrile seizures) can both arise due to mutations of SCN1A, the gene encoding alpha 1 pore-forming subunit of the Nav1.1 voltage-gated sodium channel. Owing to the inaccessibility of patient brain neurons, the precise mechanism of mild febrile seizures and SMEI remain...

Febrile seizures, or febrile convulsions (FEB), represent the most common form of childhood seizures and are believed to be influenced by variations in several susceptibility genes. Most of the associated loci, however, remain 'orphan', i.e. the susceptibility genes they contain still remain to be identified. Further orphan loci have been mapped for a related disorder, genetic (generalized) epi...

Febrile convulsions are seizures that occur due to an increase in body temperature. Data from the Makassar City Health Office 2012 reported incidence of fever unknown causes as many 54,782 cases. The study aimed know experience Bugis mothers handling febrile children working area Tamamaung Center, Panakkukang Sub-District, Makassar. Qualitative research design with phenomenological study, throu...