Inositol and tyrosine phosphatases have been implicated in inhibitory signaling by an Fc receptor for immunoglobulin G, Fc RIIB, in B cells, mast cells, and monocytes. Here, we propose a role for the Src homology 2 (SH2)-containing tyrosine phosphatase-1 (SHP-1) in Fc RIIB-mediated inhibition of Fc R signaling. Coexpression of SHP-1 enhances Fc RIIB-mediated inhibition of Fc RIIA phagocytosis i...

Nanofibers containing ferrocene (Fc) have been prepared for the first time by electrospinning. In this paper, Fc was dispersed uniformly throughout the poly(vinypyrrolidone) (PVP) matrix for the purpose of combining the properties of PVP and Fc. The effects of solvents and Fc concentration on the morphologies and diameters of nanofibers were investigated. In the DMF/ethanol solvent, the morphol...

Macrophage proliferation can be stimulated by phagocytosis and by cross-linking of Fc receptors (Fc R). In this study, we investigated the role of Fc Rand the signaling cascades that link Fc R activation to cell cycle progression. This effect was mediated by the activating Fc R, including Fc RI and III, via their Fc subunit. Further investigation revealed that the cell cycle machinery was activ...

Polymorphonuclear neutrophil (PMN) phagocytic function has been shown to be impaired in some patients with periodontitis. PMN constitutively express members of two immunoglobulin G receptor (Fc gammaR) classes: Fc gammaRIIa (CD32) and Fc gammaRIIIb (CD16). Both receptors exhibit genetically determined structural and functional biallelic polymorphisms, which have been shown to influence PMN phag...

Current models of Fc gamma R signal transduction in monocytes describe a molecular cascade that begins upon clustering of Fc gamma R with the phosphorylation of critical tyrosine residues in the cytoplasmic domains of Fc gamma RIIa or the gamma-chain subunit of Fc gamma RI and Fc gamma RIIIa. The cascade engages several other tyrosine-phosphorylated molecules, either enzymes or adapters, to man...

PURPOSE Febrile convulsion (FC) and Tourette syndrome (TS) are both common neurological disorders in infants and children. Both disorders share clinical similarities, such as paroxysmal symptoms with normal neurodevelopment and expected remission over time. This population-based study investigated the association between FC with TS during childhood neurodevelopment. METHOD We used the Taiwan ...

Abstract In order to evaluate crop water stress index (CWSI) and canopy temperature of wheat cultivars under terminal drought stress, a field experiment was conducted at the Agricultural Research Station of Shiraz University, Shiraz, during 2009 growing season. Five wheat cultivars including Shiraz, Bahar, Pishtaz, Sistan and Yavaros and four levels of water regime including well watering [Irr...

Three different classes of Fc receptors for IgG (Fc gamma R) are currently distinguished in humans, of which polymorphonuclear phagocytes (PMN) normally express both low-affinity receptor classes--Fc gamma RII (CD32) and Fc gamma RIII (CD16). During therapy with granulocyte colony-stimulating factor (G-CSF), neutrophils from patients with various malignancies and different hematologic disorders...

Due to the long serum half-life provided by the neonatal Fc receptor (FcRn) recycling, the IgG1 Fc has been pursued as the fusion partner to develop therapeutic Fc-fusion proteins, or as the antibody-derived scaffold that could be engineered with antigen-binding capabilities. In previous studies, we engineered the monomeric Fc by mutating critical residues located on the IgG1 Fc dimerization in...