OBJECTIVE To assess the efficacy and safety of duloxetine in patients with chronic fatigue syndrome. METHODS A 12-week, randomized, double-blind study was designed to compare duloxetine 60-120 mg/d (n = 30) with placebo (n = 30) for efficacy and safety in the treatment of patients with chronic fatigue syndrome. The primary outcome measure was the Multidimensional Fatigue Inventory general fat...

BACKGROUND AND AIM Fatigue is a common and bothersome symptom in inflammatory bowel disease (IBD) patients. The study was aimed to determine the relationship of biological and psychological factors with IBD-related fatigue. METHODS Consecutive clinically inactive IBD outpatients receiving immunosuppressants or biological drugs were enrolled between January and December 2013. Patients complete...

Traditional brain activation studies using neuroimaging such as functional magnetic imaging (fMRI) have shown that muscle fatigue at submaximal intensity level is associated with increased brain activity in various cortical regions from lowto highorder motor centers. However, how these areas might interact remain unclear since previous activation studies related to motor control could not revea...

Musculoskeletal disorder (MSD) is one of the major health problems in mechanical work especially in manual handling jobs. Muscle fatigue is believed to be the main reason for MSD. Posture analysis techniques have been used to expose MSD risks of the work, but most of the conventional methods are only suitable for static posture analysis. Meanwhile the subjective influences from the inspectors c...

Hallucinations remain problematic in Parkinson's disease (PD). Various factors have been studied, and many previous studies identified risk factors for hallucinations, such as sleep disorders. At the same time, fatigue is a common symptom in Parkinson's disease, and any factors associated with fatigue in PD have been reported. Factors associated with fatigue in PD are likely to be similar to ri...

Objectives: A preliminary open label study was initiated to determine if a combination oral supplement containing a mixture of phosphoglycolipids, coenzyme Q10 and microencapsulated NADH could affect fatigue levels in long-term patients with intractable fatigue. Fatigue was determined by the validated Piper Fatigue Scale before, during and after the trial. Participants included 58 patients (30 ...

BACKGROUND Fatigue is a common and frequently observed complaint among older adults. However, knowledge about the nature and correlates of fatigue in old age is very limited. OBJECTIVE This study examined the relationship of functional indicators, psychological and situational factors and fatigue for 210 octogenarians and centenarians from the Georgia Centenarian Study. METHODS Three indica...

Fatigue is an indispensable bioalarm to avoid exhaustive state caused by overwork or stresses. It is necessary to elucidate the neural mechanism of fatigue sensation for managing fatigue properly. We performed H(2) ( 15)O positron emission tomography scans to indicate neural activations while subjects were performing 35-min fatigue-inducing task trials twice. During the positron emission tomogr...

Many traffic accidents are caused by drivers with fatigue states. It is important to detect fatigue states of drivers from their eye opening degrees, namely normal, dozing and fatigue. The paper proposes a fatigue state recognition algorithm that combines independent component analysis (ICA) and one-dimensional hidden Markov model (HMM) together. The algorithm firstly does binarisation processi...

AIM To evaluate the bending fatigue lifetime of nickel-titanium alloy (NiTi) and stainless steel (SS) endodontic files using finite element analysis. METHODOLOGY The strain-life approach was adopted and two theoretical geometry profiles, the triangular (TR) and the square cross-sections, were considered. Both low-cycle fatigue (LCF) lifetime and high-cycle fatigue (HCF) lifetime were evaluate...