As a chronic lung condition, obstructive pulmonary disease (COPD) is well-known. our understanding of COPD’s consequences has grown, hypertension (PH) drawn growing amount attention. Patients’ quality life significantly impacted by the higher mortality and poor prognosis COPD patients with PH, there are still no effective medications available to treat condition. The development medication ther...

Previous studies have shown that smoking is strongly associated with atherosclerosis and coronary vascular disease. Rho-kinase plays an important role in various cellular functions associated with atherosclerosis and hypertension. However, there is no information on the relationship between smoking and Rho-kinase activity in humans. The purpose of this study was to determine the Rho-kinase acti...

MRCKα and MRCKβ (myotonic dystrophy kinase-related Cdc42-binding kinases) belong to a subfamily of Rho GTPase activated serine/threonine kinases within the AGC-family that regulate the actomyosin cytoskeleton. Reflecting their roles in myosin light chain (MLC) phosphorylation, MRCKα and MRCKβ influence cell shape and motility. We report further evidence for MRCKα and MRCKβ contributions to the ...

Hyperlipidemia is a major cardiovascular risk factor associated with progressive cerebrovascular dysfunction and diminished collateral perfusion in stroke. Rho-associated kinase (ROCK) may be an important mediator of hyperlipidemic vascular dysfunction. We tested the efficacy of acute or chronic ROCK inhibition on the size of dynamic perfusion defect using laser speckle flowmetry in hyperlipide...

OBJECTIVE Erythrocyte deformability, which can be influenced by various intracellular signaling mechanisms, such as nitric oxide, cAMP, cGMP, and protein kinases, is the most important physiological factor providing the blood flow in microcirculation. However, the functional significance of the Rho/Rho-kinase pathway, which contributes cell shape changes and the reorganization of the actin cyto...

Objective: To investigate the effect of butylphthalide combined with fasudil in treatment subarachnoid hemorrhage (SAH) cerebral vasospasm (CVS) on inflammatory factors, cognitive function and vascular endothelial function.
 Methods: It is a retrospective study which total 104 patients SAH CVS admitted to Baoding First Central Hospital from July 2020 February 2022 were selected randomly di...