Schistosoma japonicum, Fasciola hepatica and F. gigantica are digenetic trematodes and, therefore, possess similar life cycles. While schistosomiasis japonica has for a long time been recognised as a major disease of both humans and animals, infection with fasciolids has only been considered of relevance to animals. However, a number of recent reports indicate that fasciolosis is becoming a ser...

Aim of present study was to screen medicinal plants for flukicidal activity in vitro to develop alternative sources of treatment for trematodes infection. For this purpose, crude methanolic extracts (CME) of Cymbopogn jwarancusa and Conyza canadensis were prepared and live adult flukes viz; Fasciola gigantica, and Paramphistomum cervi isolated from liver and bile ducts of slaughtered buffalo we...

Nitric oxide (NO) and NO-related pathways have the potential to play critical roles in the helminthes life cycle. Nitric oxide and nitric oxide synthase(NOS) in the parasitic trematode Fasciola gigantica were investigated. Two forms of F. gigantica nitric oxide synthase were detected after chromatography on CM-cellulose. The NOS II had the highest specific activity. NOS II was purified to homog...

The ornithine-urea cycle has been investigated in Fasciola gigantica. Agrinase had very high activity compared to the other enzymes. Carbamoyl phosphate synthetase and ornithine carbamoyltransferase had very low activity. A moderate enzymatic activity was recorded for argininosuccinate synthetase and argininosuccinate lyase. The low levels of F. gigantica urea cycle enzymes except to the argina...

Fascioliasis is among important parasitic diseases which limit productivity of ruminants in particular cattle. Fasciola hepatica and Fasciola gigantica are the two liver flukes commonly reported to cause fascioliasis in ruminants. Fasciola hepatica may be acquired by man, but not directly from cattle. A person must ingest the metacercaria in order to become infected. The geographical distributi...

BACKGROUND Increased reports of human infections have led fasciolosis, a widespread disease of cattle and sheep caused by the liver flukes Fasciola hepatica and Fasciola gigantica, to be considered an emerging zoonotic disease. Chemotherapy is the main control measure available, and triclabendazole is the preferred drug since is effective against both juvenile and mature parasites. However, res...

background: aspartate transaminase (ast) is an important enzyme in parasite and liver tissue. the purpose of this investigation is to evaluate triclabendazole (tcbz) effect on ast activity of fasciola gigantica parasite. to compare of enzyme level of parasite and its host tissue, enzyme activity of f. gigantica parasite and liver tissues were also determined. method: the livers were collected f...