Sambandam, Nandakumar, Dominique Morabito, Cory Wagg, Brian N. Finck, Daniel P. Kelly, and Gary D. Lopaschuk. Chronic activation of PPAR is detrimental to cardiac recovery after ischemia. Am J Physiol Heart Circ Physiol 290: H87–H95, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00285.2005.— High fatty acid oxidation (FAO) rates contribute to ischemia-reperfusion injury of the m...

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Inherited defect in very-long-chain acyl-CoA dehydrogenase (VLCAD), a mitochondrial enzyme catalyzing the initial step of long-chain fatty acid beta-oxidation (FAO), is one of the most frequent FAO enzyme defects. VLCAD deficiency is associated with clinical manifestations varying in severity, tissue involvement and age of onset. The molecular basis of VLCAD deficiency has been elucidated but t...

Undernutrition and hunger have always formed the foundation of the Food and Agriculture Organisation’s (FAO) mandate. Working in collaboration with the International Dietary Energy Consultative Group (IDECG), FAO began to examine both appropriate cut-off points of the body mass index (BMI) at the lower end of the spectrum and the functional consequences of low BMI (<16.0 = Category III Chronic ...

BACKGROUND Lipotoxicity may be a key contributor to the pathogenesis of cardiac abnormalities in mitochondrial long-chain fatty acid β-oxidation (FAO) disorders. Few data are available on myocardial lipid levels and cardiac performance in FAO deficiencies. The purpose of this animal study is to assess fasting-induced changes in cardiac morphology, function, and triglyceride (TG) storage as a co...

Expression of the galectin-1 (L-14-I) gene, elevated in most differentiated and transformed cell lines, has been studied in cell hybrid systems. Fusion of L-14-I nonproducing rat liver differentiated FAO cells with dedifferentiated rat liver BRL3A cells leads to extinction of liver-specific gene expression while L-14-I mRNA levels remain high. Interspecific hybrids produced by fusion of tumorig...

Studies have shown that decreased mitochondrial content and function are associated with hepatic steatosis. We examined whether peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) overexpression and a subsequent increase in mitochondrial content and function in rat primary hepatocytes (in vitro) and Sprague-Dawley rats (in vivo) would comprehensively alter mitochondrial lipid m...

In 2010, the Food and Agriculture Organization of the United Nations (FAO) estimated that 16 million hectares of forest per year were lost globally in the 1990s ( FAO 2010 ), and approximately 12.5 million hectares/year were lost in countries with primate populations, an area just smaller than Greece or the US State of Mississippi (Chapman and Peres 2001 ; Chapman and Gogarten 2012 ). In contra...

RATIONALE Pressure overload cardiac hypertrophy, a risk factor for heart failure, is associated with reduced mitochondrial fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) proteins that correlate in rodents with reduced PGC-1α expression. OBJECTIVE To determine the role of PGC-1β in maintaining mitochondrial energy metabolism and contractile function in pressure overload hype...

The main goal of this study is to evaluate the potential of the FAO-56 dual technique for the estimation of regional evapotranspiration (ET) and its constituent components (crop transpiration and soil evaporation), for two classes of vegetation (olives trees and cereals) in the semi-arid region of the Kairouan plain in central Tunisia. The proposed approach combines the FAO-56 technique with re...