نتایج جستجو برای: fanconi anemia patients
تعداد نتایج: 2119640 فیلتر نتایج به سال:
A genome-wide siRNA screen identiiies the FA/BRCA pathway as the strongest predictor of cisplatin response in head and neck cancer cells. ABSTRACT Objective: Patients with advanced head and neck squamous cell carcinoma (HNSCC) are generally treated with cisplatin-containing chemoradiation protocols. Although cisplatin is a low-priced and often used addition to radiation, it causes severe toxici...
Fanconi Anemia (FA) is a rare autosomic recessive and X-linked disease with chromosomal instability after exposure to crosslinking agents as the hallmark. Clinical features of FA are somatic malformations, progressive bone marrow failure and cancer proneness, however there is wide clinical heterogeneity. The symptom most frequently and early associated with morbidity and mortality is progressiv...
Fanconi anemia (FA) consists of a group of at least five autosomal recessive disorders that share both clinical (e.g., birth defects and hematopoietic failure) and cellular (e.g., sensitivity to cross-linking agents and predisposition to apoptosis) features with each other. However, a common pathogenetic link among these groups has not been established. To identify genetic pathways that are alt...
Genes of the Fanconi complementation groups [Fanconi anemia (FA) genes] are suggested to be involved in homologous DNA recombination and produce FA when two allelic mutations are inherited. BRCA2 is an FA gene and additionally conveys an inherited risk for breast, ovarian, and pancreatic cancer for individuals carrying a single mutated allele [N. G. Howlett et al., Science (Wash. DC), 297: 606-...
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