BACKGROUND Patients with venous thromboembolic disease may present with different clinical manifestations. Factor V Leiden mutation leading to resistance to activated protein C is associated with a sevenfold increased risk for presenting with deep-vein thrombosis. It is not yet established whether carriers of the mutation have a similarly increased risk for manifesting with pulmonary embolism. ...

Purpose. To describe a patient with two episodes of deep venous thrombosis and factor V Leiden mutation who presented with central retinal vein occlusion (CRVO) despite prophylactic use of warfarin sodium (Coumadin). Methods. A case report of a 44-year-old woman with a history of recurrent deep venous thrombosis and Factor V Leiden mutation was placed on lifelong prophylactic therapy with warfa...

It has recently been postulated that thrombophilia may have a role in the aetiology of Perthes' disease. The published reports, however, remain conflicting. In this study a retrospective analysis of the coagulation parameters was made in 47 patients with Perthes' disease and the results compared with the clinical data. Five patients with Factor V Leiden mutation were found (10.6%) and surprisin...

Troponin-tropomyosin interactions. Fluorescence studies of the binding of troponin, troponin T, and chymotryptic tropo-nin T fragments to specifically labeled tropomy-osin. To the Editor: Individuals heterozygous for the factor V Leiden mutation have a seven-fold higher risk to develop venous thrombosis than wild-type (WT) individuals (1). The allele frequency of factor V Leiden in Europeans is...

INTRODUCTION Osteonecrosis (ON) of the femoral head (ONFH), a debilitating bone disease characterized by cellular death in the bone tissue, can lead to collapse of the architectural bony structure and joint function loss. Although many conditions, such as steroids, alcoholism, coagulation defects, storage diseases, marrow-infiltrating diseases, and some autoimmune diseases, can increase the ris...

BACKGROUND Because the venous thromboembolisms (VTEs) due to the coagulation factor V R506Q (FV Leiden) mutation is often seen in Caucasians, the VTE onset in Japan has not been reported. CASE PRESENTATION A 34-year-old man from north Africa experiencing sudden dyspnea went to a hospital for advice. The patient had pain in his right leg and a high plasma D-dimer level. A contrast-enhanced com...

BACKGROUND AND OBJECTIVES Oral contraceptives (OC) and inherited thrombophilia are well-known risk factors associated with venous thromboembolism (VTE). However, there are only few studies on the risk of VTE in women with inherited thrombophilia who use oral contraceptives. DESIGN AND METHODS We performed a retrospective family cohort study of 325 women belonging to 97 families with inherited...