Familial spastic paraplegia (FSP) is a heterogeneous group of disorders characterized primarily by progressive lower limb spasticity and weakness. More than 50 disease loci have been described with different modes of inheritance. In this study, we identified a novel missense mutation (c.803G>A, p.R268Q) in the plasma membrane calcium ATPase (PMCA4, or ATP2B4) gene in a Chinese family with autos...

Many gene regulatory networks are modelled at the mesoscopic scale, where chemical populations change according to a discrete state (jump) Markov process. The chemical master equation (CME) for such a process is typically infinite dimensional and unlikely to be computationally tractable without reduction. The recently proposed finite state projection (FSP) technique allows for a bulk reduction ...

The aims of this study were to fabricate a novel titanium/silicon carbide (Ti/SiC) metal matrix nanocomposite (MMNC) by friction stir processing (FSP) and to investigate its microstructure and mechanical properties. In addition, the adhesion, proliferation and osteogenic differentiation of rat bone marrow stromal cells (BMSCs) on the nanocomposite surface were investigated. The MMNC microstruct...

A fundamental problem for overlay networks is to safely exclude leaving nodes, i.e., the nodes requesting to leave the overlay network are excluded from it without affecting its connectivity. There are a number of studies for safe node exclusion if the overlay is in a well-defined state, but almost no formal results are known for the case in which the overlay network is in an arbitrary initial ...

The dynamic characteristics of a continuous rigid-frame bridge with fabricated super-high piers (CRFB-FSP) connected by grouting sleeves and adjacent beam bridges (AB) are significantly different, they prone to pounding under earthquake excitation. At present, the response between CRFB-FSP AB is still unclear, impact on seismic performance in exploratory stage. In this study, two 1/20 scaled mo...

Bi-Fe oxides are stable materials with potential photocatalytic activity under solar light photons. So far, however the of pure-phase nanosized mullite-Bi2Fe4O9 has not been studied. Usually, synthesis is hampered by co-formation perovskite BiFeO3. Herein we demonstrate that nanoparticles prepared Flame Spray Pyrolysis (FSP) technology highly efficient O2 production photocatalysts, achieving &g...

In the present research work, friction stir processing (FSP) has been adopted for fabri­cation of nano-hydroxyapatite (nHAP) reinforced AZ91-D Mg-alloy matrix surface com­posite (NMMSC). The NMMSC was developed to replace conventional bio-implants materials short-term usage. prepared by adding nHAp rein­forcement in 12.5 % volumetric proportion alloy using grooving technique followed FSP. FSP p...

In 1993 the interconnection of three local ATM-based networks in Berlin was initiated by DeTeBerkom , the Gesellschaft für Mathematik und Datenverarbeitung (GMD) and the Technical University of Berlin (TUB). This paper describes the goals of this Berlin ATM LAN Interconnection (BALI) [Hartenthaler 94] and presents first results. Section 1 introduces the infrastructure of the BALI network in its...

We demonstrate the refinement and uniform distribution of the crystalline dendritic phase by friction stir processing (FSP) of titanium based in situ ductile-phase reinforced metallic glass composite. The average size of the dendrites was reduced by almost a factor of five (from 24 μm to 5 μm) for the highest tool rotational speed of 900 rpm. The large inter-connected dendrites become more frag...