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This study aimed to establish a practical and convenient method of predicting intestinal availability (F(g)) in humans for highly permeable compounds at the drug discovery stage, with a focus on CYP3A4-mediated metabolism. We constructed a "simplified F(g) model," described using only metabolic parameters, assuming that passive diffusion is dominant when permeability is high and that the effect...

We consider topological indices I that are sums of f(deg(u))f(deg(v)), where {u, v} are adjacent vertices and f is a function. The Randić connectivity index or the Zagreb group index are examples for indices of this kind. In earlier work on topological indices that are sums of independent random variables, we identified the correlation between I and the edge set of the molecular graph as the ma...

It was recently shown that an interesting class of trees maximizes the MerrifieldSimmons index and minimizes the Hosoya index and energy among all trees with given number of vertices and maximum degree. In this paper, we describe how these trees (which we will call F-trees) can be constructed algorithmically by means of so-called F-expansions, which are very similar to ordinary base-d digital e...

BACKGROUND Dysfunctional spinal circuit may play a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). The purpose of this study was to use F waves for assessment of segmental motoneuronal excitability following upper motor neuron (UMN) dysfunctions in ALS. METHODS We studied the F waves of 152 ulnar nerves recorded from abductor digiti minimi in 82 patients with ALS. Two grou...

We study the global inversion of a continuous nonsmooth mapping f : R → R, which may be non-locally Lipschitz. To this end, we use the notion of pseudo-Jacobian map associated to f , introduced by Jeyakumar and Luc, and we consider a related index of regularity for f . We obtain a characterization of global inversion in terms of its index of regularity. Furthermore, we prove that the Hadamard i...

Let U be an open subset of a locally compact metric ANR X and let f : U → X be a continuous map. In this paper we study the fixed point index of the map that f induces in the n-symmetric product of X, Fn(X). This index can detect the existence of periodic orbits of period ≤ n of f , and it can be used to obtain the Euler characteristic of the n-symmetric product of a manifold X, χ(Fn(X)). We co...

This article handles the problem of validating the results of nested (as opposed to ”flat”) clusterings. It shows that standard external validation indices used for partitioning clustering validation, like Rand statistics, Hubert Γ statistic or F-measure are not applicable in nested clustering cases. Additionally to the work, where F-measure was adopted to hierarchical classification as hF-meas...

A measurement of the angular and polarisation dependence of the reflectance of an EM1 9124B KaCsSb bialkali photocathode, with the photomultiplier immersed in water, has allowed an unambiguous determination of the KzCsSb complex refractive index (2.7 f 0.1 + i( 1.5 f 0.1) at 442 nm wavelength) and thickness (23 f 2 nm) The wavelength dependence of the refractive index has been obtained from a m...

Recently, Fullér et al. [Fuzzy Sets and Systems, 2010] introduced a new f -weighted index of interactivity, ρf (A,B), between marginal possibility distributions A and B of a joint possibility distribution C for any weighting function f . They also left two open questions in connection with the lower limit for f -weighted possibilistic correlation coefficient related to the improved index of int...