Design and implementation of distributed algorithms often involve many subtleties due to their complex structure, nondeterminism, and low atomicity as well as occurrence of unanticipated physical events such as faults. Thus, constructing correct distributed systems has always been a challenge and often subject to serious errors. This is essentially due to the fact that we currently lack discipl...

Dengue viruses (DENVs) cause dengue fever which is an important mosquito-borne disease in tropical areas. Generally, DENV does not cause cellular damage in mosquito cells. However, alterations in cytosolic calcium ions ([Ca2+]cyt) and the mitochondrial membrane potential (MMP), as well as accumulated reactive oxygen species (ROS), including superoxide anions (O2∙-) and hydrogen peroxide (H2O2),...

We used the rat nerve growth factor receptor ectodomain (NGFRe) and Escherichia coli ss-lactamase to dissect the functions of Saccharomyces cerevisiae BiP/Kar2p in vivo. Both were fused to the Hsp150Delta-polypeptide, which promotes proper folding of heterologous proteins which otherwise are misfolded in the yeast ER. Hsp150Delta-NGFRe and Hsp150Delta-beta-lactamase acquired disulfides and were...

Not much is known about the features that determine the biological stability of a molecule retained in the endoplasmic reticulum (ER). Ig light (L) chains that are not secreted in the absence of Ig heavy (H) chain expression bind to the ER chaperone BiP as partially folded molecules until they are degraded. Although all Ig L chains have the same three-dimensional structure when part of an antib...

Troglitazone (TRO), an effective thiazolidinedione antidiabetic agent, was reported to produce idiosyncratic hepatotoxic effects in some individuals. In contrast, rosiglitazone (RSG), in the same group of agents, has no significant toxic effects and now is widely used. In this study, human hepatoma (HepG2) cell lines were exposed to various doses of TRO as well as RSG (0, 25, 50, and 75 microM)...

We propose and study a new type of facility location selection query, the top-k most influential location selection query. Given a set M of customers and a set F of existing facilities, this query finds k locations from a set C of candidate locations with the largest influence values, where the influence of a candidate location c (c ∈ C) is defined as the number of customers in M who are the re...

INTRODUCTION Anti-citrullinated protein/peptide antibodies (ACPAs) are highly specific to rheumatoid arthritis (RA) patients and are thought to have a close relationship with the pathogenesis of arthritis. Several proteins, including fibrinogen, vimentin, and alpha-enolase, were reported as ACPA-target antigens, and their importance in RA pathogenesis was widely proposed. We identified citrulli...

The family of the spin crossover (SCO) compounds based on the 1-bpp unit has furnished striking examples of how subtle changes in the crystal packing have important consequences in their spin transition. Small modifications of the 1-bpp unit itself have been recently reported, obtaining the indazolyl and pirazolyl derivatives [FeII(1-bip)]2+ (1, 1-bip = 2,6-bis(indazol-1-yl)pyridine), [FeII(1,2...

Cubic equations of state (CEoSs) are extensively used in academia and industry for their consistency, reliability, even under extrapolation conditions, capacity to predict phase-equilibrium energetic properties with acceptable accuracy. The optimal parametrization a pure-component CEoS, prerequisite the development any CEoS mixtures, is discussed first. binary interaction parameter (BIP) involv...

Researches on the development of teaching materials in universities learning process to Improving higher-order thinking plant Botany courses based local are currently very necessary. Various forms were developed critical skills. One them is a popular scientific book. This study aims test practicality book (BIP) Swamp Plants improving students' skills studying Higher Plant Botany. The type resea...