نتایج جستجو برای: f 18 18f
تعداد نتایج: 643817 فیلتر نتایج به سال:
Over the past 40 years, much of the author's research, both computational and experimental, has involved collaborations. This Perspective describes some of the author's collaborative research in eight different areas of organic and theoretical chemistry: (1) hydrocarbons containing unsaturatively, 1,3-bridged cyclobutane rings, (2) the use of orbital topology for predicting the ground states of...
Objective(s): The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-[18F]FACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.Methods: Anti-[18F]FACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET...
The ability to assess the distribution and extent of tau pathology in Alzheimer's disease and progressive supranuclear palsy in vivo would help to develop biomarkers for these tauopathies and clinical trials of disease-modifying therapies. New radioligands for positron emission tomography have generated considerable interest, and controversy, in their potential as tau biomarkers. We assessed th...
BACKGROUND Florbetapir F 18 (F-AV-45) is a positron emission tomography imaging ligand for the detection of amyloid aggregation associated with Alzheimer disease. Earlier data showed that florbetapir F 18 binds with high affinity to β-amyloid (Aβ) plaques in human brain homogenates (Kd=3.7 nM) and has favorable imaging pharmacokinetic properties, including rapid brain penetration and washout. T...
BACKGROUND The investigation of disease progression provides important information on the dynamics of cell death in Parkinson disease (PD). OBJECTIVE To determine the progression of dopaminergic impairment in PD with the use of positron emission tomography (PET). DESIGN Longitudinal prospective cohort study with a follow-up period of 64.5 +/- 22.6 months (mean +/- SD). SETTING University ...
PURPOSE Previously, we showed successful imaging of xenografts that express the prostate-specific membrane antigen (PSMA) using small-animal positron emission tomography (PET) and the radiolabeled PSMA inhibitor N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-S-[11C]methyl-l-cysteine. Herein, we extend that work by preparing and testing a PSMA inhibitor of the same class labeled with fluorine-18. EX...
Abstract Background 6-[ 18 F]fluoro- l -3,4-dihydroxyphenyl alanine ([ F]FDOPA) is a commonly used PET tracer for the detection and staging of neuroendocrine tumors. In tumors, [ F]FDOPA decarboxylated to F]dopamine via enzyme amino acid decarboxylase (AADC), leading increased uptake when there AADC activity. Recently, in our hospital, new GMP compliant multi-dose production has been developed,...
introduction:myocardial 18f-fdg uptake is highly variable in oncologic whole body 18f-fdg pet/ct studies, ranging from quite intense to minimal distribution. intense or heterogeneous myocardial 18f-fdg uptake is undesirable as it may interfere with the visual or quantitative evaluation of tumoral invasion and metastases in pericardium, myocardium or adjacent mediastinal structures. the diet, as...
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