glioblastoma is the most common and the most lethal primary brain cancer. this malignancy is highly locally invasive, rarely metastatic and resistant to current therapies. little is known about the distinct molecular biology of glioblastoma multiforme (gbm) in terms of initiation and progression. so far, several molecular mechanisms have been suggested to implicate in gbm development. homeodoma...

PURPOSE To examine the expression of the major isoforms of cyclic guanosine monophosphate (cGMP)-dependent protein kinase (cGK) in mouse eye. METHODS Immunohistochemical localization of cGMP in mouse eye cryosections was performed using an anti-cGMP antibody, followed by visualization with indirect fluorescence microscopy. The presence of types Ialpha, Ibeta, and II cGK mRNAs in mouse eye ext...

results males (8,593 patients) were more likely to have eye trauma than females (1,262). the mean age for the outpatient cases was 20.3 ± 16.39 years and for the inpatient cases it was 22.7 ± 18.95 years. the workplace was the most common site for trauma and the cornea was the most reported anatomically injured site. for those patients who had not used safety and protection equipment, 93.1% wer...

purpose: dry eye syndrome is a multifactorial disorder of the tear film and ocular surface that results in eye discomfort, visual disturbance, and often ocular surface damage. studies suggest that the prevalence of clinically diagnosed dry eye syndrome (des) is 0.4%. to 0.5%, which is highest among women and the elderly. the burden of des can be substantial, affecting visual function, daily act...

Darwin theorized that emotional expressions originated as opposing functional adaptations for the expresser, not as distinct categories of social signals. Given that two thirds of the eye's refractive power comes from the cornea, we examined whether opposing expressive behaviors that widen the eyes (e.g., fear) or narrow the eyes (e.g., disgust) may have served as an optical trade-off, enhancin...

We describe a method for eye pupil localization based on an ensemble of randomized regression trees and use several publicly available datasets for its quantitative and qualitative evaluation. The method compares well with reported state-of-the-art and runs in real-time on hardware with limited processing power, such as mobile devices.

PURPOSE There are several aspects of the visual system that may be regulated by Ca2+- and calmodulin (CaM)-stimulated protein phosphatase. In the present study, the distribution and characterization of calcineurin (CaN) in bovine eye was determined. METHODS Whole bovine eyes were either homogenized for purification or regionally dissected to determine CaN localization and activity. Dissected ...

Reaching towards a visual object in the absence of visual referents relies on a chain of information, from the sensory signals encoding the object's image on the retina, to the motor signals driving the hand. One link in this chain is an extraretinal eye position signal (EEPS), which specifies the position of the eye in the head. EEPS must be updated in precise coordination with the eye's rapid...

Tissue polarity in Drosophila is regulated by a number of genes that are thought to function in a complex, many of which interact genetically and/or physically, co-localize, and require other tissue polarity proteins for their localization. We report the enhancement of the strabismus tissue polarity phenotype by mutations in two other tissue polarity genes, flamingo and prickle. Flamingo is aut...

In this paper we present a general technique for face and facial features localization in 2D color images with arbitrary background. In a previous work we studied an eye localization module, here we focus on mouth localization. Given in input an image that depicts a sole person, first we exploit the color information to limit the search area to candidate mouth regions, then we determine the exa...