The desmoplastic small round cell tumor (DSRCT) is a recently recognized type of primitive sarcoma defined by a predilection for young males, aggressive clinical behavior, widespread abdominal serosal involvement, and a primitive histological appearance with prominent desmoplasia and striking divergent, multilineage differentiation. Previous cytogenetic case reports have identified a recurrent ...

BACKGROUND Early warning scores (EWS) are an integral part of the care of acutely ill patients. Unfortunately, in the few studies where the accuracy of EWS has been tested it has been found to be lacking, with serious implications for quality of care. AIM To determine if the provision of computer-aided scoring could increase the accuracy and efficiency of EWS calculations, when compared with ...

Connexins (Cxs) are building unit proteins of gap junctions (GJs) that are prognostic markers in carcinomas. To investigate the role of Cx in Ewing sarcoma (EWS)/primitive neuroectodermal tumor (PNET), we examined the expression of Cx43 and Cx26 in 36 EWS/PNETs and found (1) cytoplasmic Cx43 reactivity in 28/36 (78%) cases. (2) Cx43 score was significantly correlated with overall survival (P = ...

the purpose of this study was to evaluate an extension agent's perception with respect to effectiveness of mass teaching methods employed in educational activities of irrigated wheat growing farmers in golestan province. survey and correlational methods were employed in the study. questionnaire was used as means to collect data. the study population consisted of the whole extension workers...

Summary The performance of an in-house protocol for virus detection on commercialized electrostatic wipes (EWs) was assessed experimentally by impregnating them with suspensions cytomegalovirus, adenovirus, and influenza virus, determining the recovery efficiency, repeatability, limit protocol. sensitive enough to detect 4 log10 gene copies virus. At room temperature, RNA stable EWs at least fo...

Background Emergency departments (ED) have recently been established throughout Denmark, and their organization is still under transformation. The departments are characterized by a high turnover of staff. To ensure quality of care and efficiency of work electronic whiteboards (EW) have been implemented. The EWs create an overview allowing staff to assess who need care the most and to coordinat...

The problem of demonstrating entanglement is central to quantum information processing applications. Resorting to standard entanglement witnesses requires one to perfectly trust the implementation of the measurements to be performed on the entangled state, which may be an unjustified assumption. Inspired by the recent work of F. Buscemi [Phys. Rev. Lett. 108, 200401 (2012)], we introduce the co...

BACKGROUND The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highly polymorphic in humans, and preliminary evidence suggests EWS/FLI-mediated gene expression is highly dependent on the number of GGAA mo...

In contrast to the knowledge regarding the function of chimeric Ewing sarcoma (EWS) fusion proteins that arise from chromosomal translocation, the cellular function of the RNA binding EWS protein is poorly characterized. EWS protein had been found mainly in the nucleus. In this report we show that EWS protein is not only found in the nucleus and cytosol but also on cell surfaces. After cell-sur...

Ewing sarcoma is driven by characteristic chromosomal translocations between the EWSR1 gene with genes encoding ETS family transcription factors (EWS-ETS), most commonly FLI1. However, direct pharmacological inhibition of transcription factors like EWS-FLI1 remains largely unsuccessful. Active gene transcription requires orchestrated actions of many epigenetic regulators, such as the bromodomai...