Intravascular Ultrasound (IVUS) data validation is usually performed by comparing postmortem (ex-vivo) IVUS data and corresponding histological analysis of the tissue, obtaining a reliable ground truth. The main drawback of this method is the few amount of available training dataset. In this work we propose a method to include examples from in-vivo labeled plaque to the ex-vivo training dataset...

To use blood in the Langendorff settings one has to substantially reduce the volume of the circulation circuit. The perfusion volume of a standard Langendorff system is about 100 ml and the priming volume of the smallest commercially available oxygenator is 50 ml. Simple calculations indicate that about 10-12 rats or 60-70 mice have to be sacrificed to obtain the amount of blood required to per...

BACKGROUND Accurate assessment of myocardium at risk (MaR) after acute myocardial infarction (AMI) is necessary when assessing myocardial salvage. Contrast-enhanced steady-state free precession (CE-SSFP) is a recently developed cardiovascular magnetic resonance (CMR) method for assessment of MaR up to 1 week after AMI. Our aim was to validate CE-SSFP for determination of MaR in an experimental ...

A long history of postmortem studies has provided significant insight into human brain structure and organization. Cadavers have also proven instrumental for the measurement of artifacts and nonneural effects in functional imaging, and more recently, the study of biophysical properties critical to brain stimulation. However, death produces significant changes in the biophysical properties of br...

Abstract Background Ex vivo and in detection imaging of adenosine triphosphate (ATP) is critically important for the diagnosis treatment diseases, which still remains challenges up to present. Results We herein demonstrate that ATP could be fluorescently detected imaged ex vivo. In particular, we fabricate a kind fluorescent probes, are made titanium carbide (TC) nanosheets modified with ROX-ta...

The chemical species of principal clinical interest for continuous monitoring include oxygen, carbon dioxide, pH, potassium, and glucose. Although sensors exist for all of these analytes, relatively few continuous monitors are used for blood chemistries. Reviewing the available electrochemical and optical approaches along with the expected system performance requirements provides some insight i...

Animal models of disease are an indispensable element in our quest to understand pathophysiology and develop novel therapies. Ex vivo studies have severe limitations, in particular their inability to study individual disease progression over time. In this respect, non-invasive in vivo technologies offer multiple advantages. We here used bilateral common carotid artery occlusion (BCCAO) in mice,...