INTRODUCTION: Clear cell sarcoma (CCS), also called malignant melanoma of soft parts, is an aggressive malignant soft-tissue tumor that usually develops in the tendons and aponeuroses of the extremities of young adults (Enzinger, 1965). The origin and pathogenesis of this disease are poorly understood, and beneficial therapy—except for surgical resection—has not yet been developed. The high rat...

BACKGROUND Failure to comply with clinical protocols and failure of communication to ensure delivery of the most appropriate timely clinical responses to patients whose conditions are acutely deteriorating have been shown to be significant causative factors associated with inhospital adverse events. OBJECTIVE To determine whether automated clinical alerts increase compliance with an Early War...

Ewing Sarcoma is a rare bone and soft tissue malignancy affecting children and young adults. Chromosomal translocations in this cancer produce fusion oncogenes as characteristic molecular signatures of the disease. The most common case is the translocation t (11; 22) (q24;q12) which yields the EWS-Fli1 chimeric transcription factor. Finding a way to directly target EWS-Fli1 remains a central th...

Ewing Family Tumors (Ewing Sarcoma and peripheral Primitive Neuroectodermal Tumor) are common bone and soft tissue malignancies of childhood, adolescence and young adulthood. Chromosomal translocation in these tumors produces fusion oncogenes of the EWS/ETS class, with EWS/FLI1 being by far the most common. EWS/ETS chimera are the only well established driver mutations in these tumors and they ...

An Early Warning System or EWS is a core type of data driven IoT (Internet of Things) system used for environment disaster risk and effect management. The potential benefits of using a semantic type EWS include easier sensor and data source plug-and-play, simpler, richer and more dynamic metadatadriven data analysis and easier service interoperability and orchestration. The challenges faced dur...

Ewing's sarcoma (EWS) is a highly aggressive bone cancer that affects children and adolescents. Despite advances in multimodal management, 5-year event-free survival rates for patients presenting with metastases at diagnosis remain at 25%. As key regulators of actin organization, the Rho-associated coiled-coil containing protein kinases, ROCK1 and ROCK2, have been associated with cancer dissemi...

BACKGROUND The presence of tumor-specific mutations in the cancer genome represents a potential opportunity for pharmacologic intervention to therapeutic benefit. Unfortunately, many classes of oncoproteins (e.g., transcription factors) are not amenable to conventional small-molecule screening. Despite the identification of tumor-specific somatic mutations, most cancer therapy still utilizes no...

Chromosomal translocations that create fusion oncogenes have long been recognized as a cause of human cancers such as leukemias and sarcomas (Mitelman et al., 2007), and recently have been described in prostate (Tomlins et al., 2005; Brenner and Chinnaiyan, 2009) and lung cancer (Soda et al., 2007). Drugs that target oncogenic fusions have also led to dramatic improvements in the treatment of c...

Ewing's sarcoma is associated with a fusion between the EWS and FLI1 genes, forming an EWS/FLI fusion protein. We developed a system for the identification of cooperative mutations in this tumor through expression of EWS/FLI in primary human fibroblasts. Gene expression profiling demonstrated that this system recapitulates many features of Ewing's sarcoma. EWS/FLI-expressing cells underwent gro...

Early Warning Systems (EWS) can play a crucial role in mitigating the effects of natural disasters. Modern EWSs leverage wireless sensors for real-time monitoring of natural phenomena and computing-intensive scientific applications for scenario-based prediction and analysis of sensor data. This paper presents the UrbanFlood Common Information Space (CIS), a framework facilitating the creation, ...