twenty-one patients with advanced breast cancer (7 premenopausal and 14 postmenopausal women) were treated with a combination of cyclophosphamide, doxorubicin, and cisplatin (cap). the median age of the patients was 43 years (range 36-61). this therapy was repeated every 3 weeks. nine patients (group 1) received cap as primary therapy for metastatic breast cancer, and twelve patients (group 2) ...

In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neuritogenesis, to prion diseases. We found that overactivation of ROCK signaling occurred in neuronal s...

1 Department of Endocrinology and Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA, 2 GIM Foundation, Little Rock, AR, USA, 3 Department of Internal Medicine and Hospital Medicine, Christus Trinity Mother Frances Hospital, Tyler, TX, USA, 4 Department of Policy, University of Arkansas for Little Rock, Little Rock, AR, USA, 5 Tutwiler Clinic, Tutwiler, MS, USA...

The aim of this study is to investigate the feasibility underground storage gas in Um El-Radhuma formation /Ratawi field. This an aquifer consisting a high permeable dolomitebeds overlain by impermeable anhydrite bed Rus formation. Interactive petrophysics (IP), Petrel REand Eclipse 100 softwares were used conduct well log interpretation, build reservoir simulationmodel and predict behavior dur...

This paper deals with the statistical analysis of the uniaxial compressive strength and of the elastic modulus of jointed rock masses under different confining pressures. Properties of the rock masses with different joint fabric, with and without gouge have been considered in the analysis. A large amount of experimental data of jointed rock masses from the literature has been compiled and used ...