Objective(s) Inhibitors of p38 MAP kinase are considered as suitable target in the treatment of inflammatory diseases such as rheumatoid arthritis and bowel inflammatory diseases. The development of 5-alkylthio-1-aryl-2-(4-pyridinyl) triazoles as inhibitors of p38 MAP kinase is described. These are analogues of 4- pyridinyl imidazole p38 MAP kinase inhibitor reported by Merck Research Laborator...

This paper quantitatively analyzs the map information of different scales in the range of the mapping scale by making use of landscape pattern index, and constructs an evaluation index system by the standard of cartographic generalization evaluation. It takes land use cartographic generalization in Da Xing agricultural region of Beijing for an example, evaluates on the map quality between the s...

Gaussian mixture model support vector machine (GMMSVM) with nuisance attribute projection (NAP) has been found to be effective and reliable for speaker and language recognition. In maximum a posteriori (MAP) adaptation of GMM, the relevance factor is the parameter that regulates how much the adaptation data affect the base model, which impacts the final recognition performance. In our previous ...

We argue (1) that the domains of externally mandated tests should be transparent to teachers, (2) that test maps can be used to communicate with teachers, and (3) that the most effective test maps express domains in terms of combinations of what students know and can do. We propose a device called a heuristic as the lowest level of specificity in a test map, and criteria to achieve a balance be...

Nowadays, Web-based learning systems have become popular because they can provide multiple tools, among which hierarchical maps are widely used to support teaching and learning. However, traditional hierarchical maps may let learners easily get lost within large information space. This study proposes an animated hierarchical map to address this problem. To consider the effects of different inst...

In this paper a unique map or signature of three dimensional objects is defined. The map is obtained locally, for every possible rotation of the object, by the Fourier transform of the phase-encoded range-image at each specific rotation. From these local maps, a global map of orientations is built that contains the information about the surface normals of the object. The map is defined on a uni...

We present metrics to evaluate the performance of video object segmentation and tracking methods quantitatively when groundtruth segmentation maps are not available. The proposed metrics are based on the color and motion differences along the boundary of the estimated video object plane and the color histogram differences between the current object plane and its temporal neighbors. These metric...

An evaluation of the radioactivity levels associated with naturally occurring radioactive materials has been undertaken as part of a systematic study to provide a surface radiological map of the State of Kuwait. Soil samples from across Kuwait were collected, measured and analysed in the current work. These evaluations provided soil activity concentration levels for primordial radionuclides, sp...

With the upgrade of the National Weather Service network of weather radars to dual-polarization, it has become possible to use the new radar moments to detect tornado debris. This study investigates the likelihood of observing the tornado debris signature (TDS) at different geographic locations throughout the United States given that an ongoing tornado is present. The likelihood of observing a ...

Most studies examining continental-to-global patterns of species richness rely on the overlaying of extent-of-occurrence range maps. Because a species does not occur at all locations within its geographic range, range-map-derived data represent actual distributional patterns only at some relatively coarse and undefined resolution. With the increasing availability of high-resolution climate and ...